Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARG | P37231 | 19/20 | 0.45 |
| ▸ | PPARA | Q07869 | 15/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7494345 | 0.92 | PPARG (0.47) | PPARGPPARAKDM4E | |
| SCHEMBL7486254 | 0.90 | PPARG (0.49) | PPARGPPARA | |
| SCHEMBL7487592 | 0.84 | PPARG (0.47) | PPARGPPARACYP3A4CYP2C9KCNH2 | |
| SCHEMBL7909696 | 0.83 | PPARG (0.60) | PPARGPPARACYP3A4CYP2C9KCNH2 | |
| SCHEMBL9274342 | 0.80 | PPARG (0.47) | PPARGPPARACYP3A4CYP2C9KCNH2 | |
| SCHEMBL7877637 | 0.80 | PPARG (0.47) | PPARGPPARACYP3A4CYP2C9KCNH2 | |
| SCHEMBL9286066 | 0.80 | PPARG (0.47) | PPARGPPARACYP3A4CYP2C9KCNH2 | |
| SCHEMBL7877640 | 0.80 | PPARG (0.47) | PPARGPPARACYP3A4CYP2C9KCNH2 | |
| SCHEMBL7879128 | 0.80 | PPARG (0.47) | PPARGPPARACYP3A4CYP2C9KCNH2 | |
| SCHEMBL7494333 | 0.79 | PPARG (0.47) | PPARGPPARA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0643050-B1 | Oxazolidinedione derivatives and their use as hypoglycemic agent | TAKEDA CHEMICAL INDUSTRIES LTD (JP) | 2002-04-10 | — | — | EP | claimed |
| EP-0643050-A1 | Oxazolidinedione derivatives and their use as hypoglycemic agent | Takeda Chemical Industries, Ltd. (JP) | 1995-03-15 | — | — | EP | claimed |
| US-5614544-A | HYPOGLYCEMIC AND HYPOLIPIDEMIC AGENTS | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1997-03-25 | — | — | US | disclosed |
| EP-0643050-A1 | Oxazolidinedione derivatives and their use as hypoglycemic agent | Takeda Chemical Industries, Ltd. (JP) | 1995-03-15 | — | — | EP | disclosed |