Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.49 |
| ▸ | DHODH | Q02127 | 2/20 | 0.49 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.47 |
| ▸ | GAA | P10253 | 3/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | MAPK10 | P53779 | 2/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.44 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.44 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.44 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11801755 | 1.00 | MAPT (0.49) | MAPTDHODHCYP19A1GAAALDH1A1 | |
| SCHEMBL19889940 | 0.86 | MAPK10 (0.64) | MAPTGAAALDH1A1MAPK10TDP1 | |
| SCHEMBL7497196 | 0.85 | MAPT (0.50) | MAPTCYP19A1GAAALDH1A1L3MBTL1 | |
| SCHEMBL7488984 | 0.83 | TP53 (0.55) | MAPTDHODHCYP19A1GAAALDH1A1 | |
| SCHEMBL8327933 | 0.83 | TP53 (0.55) | MAPTDHODHCYP19A1GAAALDH1A1 | |
| SCHEMBL7488989 | 0.83 | TP53 (0.55) | MAPTDHODHCYP19A1GAAALDH1A1 | |
| SCHEMBL11436210 | 0.83 | MAPT (0.47) | MAPTDHODHCYP19A1GAAALDH1A1 | |
| SCHEMBL7493239 | 0.83 | ALDH1A1 (0.45) | MAPTDHODHGAAALDH1A1L3MBTL1 | |
| SCHEMBL18707907 | 0.82 | CYP19A1 (0.54) | MAPTCYP19A1GAAALDH1A1TDP1 | |
| SCHEMBL7491261 | 0.81 | ALDH1A1 (0.56) | MAPTALDH1A1MAPK10TSHRCYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0760362-B1 | DIAMINOMETHYLIDENE DERIVATIVE | NISSHIN SEIFUN GROUP INC (JP) | 2002-08-14 | — | — | EP | disclosed |
| US-5753654-A | GASTROINTESTINAL DISORDERS | NISSHIN FLOUR MILLING CO., LTD. (JP) | 1998-05-19 | — | — | US | disclosed |
| EP-0760362-A1 | NOVEL DIAMINOMETHYLIDENE DERIVATIVE | NISSHIN FLOUR MILLING CO., LTD. (JP) | 1997-03-05 | — | — | EP | disclosed |
| US-3981717-A | ANILINO COMPOUNDS | AMERICAN CYANAMID COMPANY (US) | 1976-09-21 | — | — | US | disclosed |