Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | CASP1 | P29466 | 11/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.35 |
| ▸ | APBA1 | Q02410 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL367991 | 1.00 | SMN1; SMN2 (0.44) | SMN1; SMN2CASP1CYP3A4SLC22A6TDP1 | |
| Fumaric Acid SCHEMBL16653510 | 0.93 | SMN1; SMN2 (0.39) | SMN1; SMN2CASP1CYP3A4SLC22A6TDP1 | |
| SCHEMBL167301 | 0.83 | TDP1 (0.43) | SMN1; SMN2CASP1CYP3A4TDP1TSHR | |
| SCHEMBL8003148 | 0.82 | SMN1; SMN2 (0.40) | SMN1; SMN2CASP1CYP3A4SLC22A6TDP1 | |
| SCHEMBL7431878 | 0.82 | MAPT (0.42) | CASP1CYP3A4TDP1TSHRMAPT | |
| SCHEMBL7431887 | 0.82 | MAPT (0.42) | CASP1CYP3A4TDP1TSHRMAPT | |
| Ethylene SCHEMBL459401 | 0.81 | TSHR (0.37) | SMN1; SMN2CASP1CYP3A4TSHRMAPT | |
| SCHEMBL7773895 | 0.80 | TDP1 (0.38) | SMN1; SMN2CYP3A4TDP1TSHRMAPT | |
| SCHEMBL18280854 | 0.80 | TET2 (0.48) | SMN1; SMN2CYP3A4TDP1TSHRMAPT | |
| SCHEMBL18280853 | 0.80 | TET2 (0.48) | SMN1; SMN2CYP3A4TDP1TSHRMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0535042-B1 | ANGIOTENSIS CONVERTING ENZYME INHIBITORS | FISONS PLC (GB) | 1995-03-29 | — | — | EP | disclosed |
| US-5348978-A | Angiotensin converting enzyme inhibitors | FISONS PLC (GB) | 1994-09-20 | — | — | US | disclosed |
| EP-0535042-A1 | ANGIOTENSIS CONVERTING ENZYME INHIBITORS. | FISONS PLC (GB) | 1993-04-07 | — | — | EP | disclosed |
| WO-1992000276-A2 | ANGIOTENSIS CONVERTING ENZYME INHIBITORS | FISONS PLC (GB) | 1992-01-09 | — | — | WO | disclosed |