Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP19A1 | P11511 | 2/20 | 0.52 |
| ▸ | CYP11B1 | P15538 | 2/20 | 0.52 |
| ▸ | CYP11B2 | P19099 | 2/20 | 0.52 |
| ▸ | MAPT | P10636 | 4/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | EGFR | P00533 | 1/20 | 0.36 |
| ▸ | BTK | Q06187 | 1/20 | 0.36 |
| ▸ | ITK | Q08881 | 1/20 | 0.36 |
| ▸ | AKT1 | P31749 | 1/20 | 0.36 |
| ▸ | USP2 | O75604 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.35 |
| ▸ | TSHR | P16473 | 2/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.35 |
| ▸ | CA1 | P00915 | 1/20 | 0.35 |
| ▸ | CA2 | P00918 | 1/20 | 0.35 |
| ▸ | CA9 | Q16790 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7362484 | 0.88 | CYP19A1 (0.48) | CYP19A1CYP11B1CYP11B2MAPTTP53 | |
| SCHEMBL6804355 | 0.86 | CYP11B2 (0.47) | CYP19A1CYP11B1CYP11B2MAPTEGFR | |
| SCHEMBL7394048 | 0.84 | CYP19A1 (0.45) | CYP19A1CYP11B1CYP11B2MAPTTP53 | |
| SCHEMBL6796737 | 0.83 | MAPT (0.46) | CYP19A1CYP11B1CYP11B2MAPTEGFR | |
| SCHEMBL6796370 | 0.82 | AKT1 (0.48) | MAPTEGFRBTKITKAKT1 | |
| SCHEMBL6798622 | 0.82 | PDE4A (0.46) | PDE4BPDE4APDE4CPDE4D | |
| SCHEMBL6797019 | 0.81 | MAPT (0.48) | CYP11B1CYP11B2MAPTEGFRBTK | |
| SCHEMBL6793970 | 0.81 | MAPT (0.48) | CYP11B1CYP11B2MAPTEGFRBTK | |
| Hydrochloric Acid SCHEMBL6793114 | 0.80 | MAPT (0.47) | CYP11B1CYP11B2MAPTEGFRBTK | |
| SCHEMBL6798823 | 0.79 | CYP2A6 (0.46) | MAPTEGFRBTKITKAKT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0874845-B1 | PYRIDO (2,3-B) PYRAZINE DERIVATIVES | FUJISAWA PHARMACEUTICAL CO (JP) | 2002-03-06 | — | — | EP | disclosed |
| US-6117875-A | Pyrido (2,3-B) pyrazine derivatives | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2000-09-12 | — | — | US | disclosed |