Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP19A1 | P11511 | 2/20 | 0.48 |
| ▸ | CYP11B1 | P15538 | 2/20 | 0.48 |
| ▸ | CYP11B2 | P19099 | 2/20 | 0.48 |
| ▸ | TP53 | P04637 | 2/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | CA1 | P00915 | 1/20 | 0.38 |
| ▸ | CA2 | P00918 | 1/20 | 0.38 |
| ▸ | CA9 | Q16790 | 1/20 | 0.38 |
| ▸ | PDE4B | Q07343 | 7/20 | 0.37 |
| ▸ | PDE4D | Q08499 | 4/20 | 0.36 |
| ▸ | MAPT | P10636 | 3/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | MALT1 | Q9UDY8 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7489258 | 0.88 | CYP19A1 (0.52) | CYP19A1CYP11B1CYP11B2TP53POLB | |
| SCHEMBL7394048 | 0.87 | CYP19A1 (0.45) | CYP19A1CYP11B1CYP11B2TP53POLB | |
| SCHEMBL6805376 | 0.80 | PDE10A (0.42) | TP53PDE4BPDE4DMAPTKDM4E | |
| SCHEMBL6798260 | 0.75 | AKT1 (0.41) | TP53PDE4BPDE4DMAPTKDM4E | |
| SCHEMBL6799259 | 0.73 | ALDH1A1 (0.50) | TP53POLBPDE4BPDE4DALDH1A1 | |
| SCHEMBL6804355 | 0.72 | CYP11B2 (0.47) | CYP19A1CYP11B1CYP11B2PDE4BPDE4D | |
| SCHEMBL7360638 | 0.72 | CYP3A4 (0.48) | CYP19A1CYP11B1CYP11B2POLBPDE4B | |
| SCHEMBL6794097 | 0.70 | NPSR1 (0.41) | TP53PDE4BPDE4DMAPTKDM4E | |
| SCHEMBL6793627 | 0.70 | PDE4B (0.41) | TP53POLBPDE4BPDE4DMAPT | |
| SCHEMBL6798463 | 0.69 | ALDH1A1 (0.45) | PDE4BPDE4DMAPTMEN1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0874845-B1 | PYRIDO (2,3-B) PYRAZINE DERIVATIVES | FUJISAWA PHARMACEUTICAL CO (JP) | 2002-03-06 | — | — | EP | disclosed |
| US-6117875-A | Pyrido (2,3-B) pyrazine derivatives | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2000-09-12 | — | — | US | disclosed |
| EP-0874845-A1 | PYRIDO (2,3-B) PYRAZINE DERIVATIVES | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1998-11-04 | — | — | EP | disclosed |
| WO-1997024355-A1 | PYRIDO (2,3-B) PYRAZINE DERIVATIVES | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1997-07-10 | — | — | WO | disclosed |