SCHEMBL7489559

SCHEMBL7489559

CC(C)(C)OC(=O)N1CCN(c2ccc(N3CC(COS(C)(=O)=O)OC3=O)cc2F)CC1

nearest known ligand 0.54

Predicted protein targets (top 7)

geneUniProtsupporting neighboursconfidence
MAOB P27338 12/20 0.54
MAOA P21397 5/20 0.54
LMNA P02545 1/20 0.50
PTGS1 P23219 1/20 0.50
CALML3 P27482 1/20 0.50
SDHA P31040 1/20 0.50
F10 P00742 7/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6110586 1.00 MAOB (0.54) MAOBMAOALMNAPTGS1CALML3
SCHEMBL2499941 0.90 MAOA (0.43) MAOBMAOALMNAPTGS1CALML3
SCHEMBL2483101 0.90 MAOA (0.43) MAOBMAOALMNAPTGS1CALML3
SCHEMBL7485004 0.89 MAOB (0.57) MAOBMAOALMNAPTGS1CALML3
SCHEMBL7484998 0.89 MAOB (0.57) MAOBMAOALMNAPTGS1CALML3
SCHEMBL6649670 0.89 MAOB (0.51) MAOBMAOALMNAPTGS1CALML3
SCHEMBL6649666 0.89 MAOB (0.51) MAOBMAOALMNAPTGS1CALML3
SCHEMBL5810297 0.88 MAOB (0.58) MAOBMAOALMNAPTGS1CALML3
SCHEMBL5412271 0.88 MAOB (0.56) MAOBMAOALMNAPTGS1CALML3
SCHEMBL6402366 0.87 GPR119 (0.51) MAOBMAOALMNAPTGS1CALML3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0640077-B1 OXAZOLIDINONES CONTAINING A SUBSTITUTED DIAZINE MOIETY AND THEIR USE AS ANTIMICROBIALS UPJOHN CO (US) 2002-06-26 EP disclosed
CN-1044236-C Oxazolidinone antimicrobials containing substituted diazine moieties PHARMACIA UPJOHN CO (US) 1999-07-21 CN disclosed
US-5700799-A MICROBIOCIDES FOR TREATING HUMAN OR ANIMAL DISEASES PHARMACIA & UPJOHN COMPANY (US) 1997-12-23 US disclosed
US-5547950-A FOR TREATING DRUG RESISTANT STAPHYLOCOCCUS AND STREPTOCOCCUS INFECTIONS THE UPJOHN COMPANY (US) 1996-08-20 US disclosed
WO-1993023384-A1 OXAZOLIDINONES CONTAINING A SUBSTITUTED DIAZINE MOIETY AND THEIR USE AS ANTIMICROBIALS THE UPJOHN COMPANY (US) 1993-11-25 WO disclosed