Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 3/20 | 0.70 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.70 |
| ▸ | RAB9A | P51151 | 9/20 | 0.68 |
| ▸ | NPC1 | O15118 | 4/20 | 0.68 |
| ▸ | MAPT | P10636 | 1/20 | 0.60 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.60 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.56 |
| ▸ | POLB | P06746 | 1/20 | 0.53 |
| ▸ | APEX1 | P27695 | 1/20 | 0.53 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.53 |
| ▸ | TSHR | P16473 | 2/20 | 0.52 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.52 |
| ▸ | ATM | Q13315 | 2/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30084003 | 1.00 | HPGD (0.70) | HPGDNPSR1RAB9ANPC1MAPT | |
| SCHEMBL3626811 | 0.93 | RAB9A (0.72) | HPGDNPSR1RAB9ANPC1MAPT | |
| SCHEMBL4728037 | 0.92 | HPGD (0.59) | HPGDNPSR1RAB9ANPC1MAPT | |
| SCHEMBL28591026 | 0.91 | RAB9A (0.66) | HPGDNPSR1RAB9ANPC1MAPT | |
| SCHEMBL13969475 | 0.90 | RAB9A (0.64) | HPGDNPSR1RAB9ANPC1MAPT | |
| SCHEMBL29237869 | 0.84 | HPGD (0.79) | HPGDNPSR1RAB9ANPC1MAPT | |
| SCHEMBL31030951 | 0.84 | HPGD (0.79) | HPGDNPSR1RAB9ANPC1MAPT | |
| SCHEMBL1578469 | 0.84 | RAB9A (0.83) | HPGDNPSR1RAB9ANPC1MAPT | |
| SCHEMBL18074274 | 0.83 | HPGD (1.00) | HPGDNPSR1RAB9ANPC1MAPT | |
| SCHEMBL14851782 | 0.82 | HPGD (0.49) | HPGDNPSR1RAB9ANPC1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111601797-B | Benzopiperidine or heteroaryl piperidine derivatives, preparation method and application thereof in medicines | 江苏恒瑞医药股份有限公司 | 2022-11-22 | — | — | CN | disclosed |
| CN-111601797-A | Benzopiperidine or heteroaryl piperidine derivatives, preparation method and application thereof in medicines | 江苏恒瑞医药股份有限公司 | 2020-08-28 | — | — | CN | disclosed |
| EP-0912567-B1 | CARBOLINE DERIVATIVES | ICOS CORP (US) | 2002-04-10 | — | — | EP | disclosed |
| US-6306870-B1 | PHOSPHODIESTERASE ENZYME INHIBITORS, CARDIOVASCULAR DISORDERS AND SEXUAL DISORDERS | ICOS CORPORATION | 2001-10-23 | — | — | US | disclosed |
| US-6117881-A | POTENT AND SELECTIVE INHIBITORS OF CYCLIC GUANOSINE 3',5'-MONOPHOSPHATE SPECIFIC PHOSPHODIESTERASE | ICOS CORPORATION (US) | 2000-09-12 | — | — | US | disclosed |
| US-6043252-A | A POTENT AND SELECTIVE INHIBITORS OF CYCLIC GUANOSINE 3',5'-MONOPHOSPHATE SPECIFIC PHOSPHODIESTERASE (CGMP-SPECIFIC PDE); TREATING CARDIOVASCULAR DISORDERS AND ERECTILE DYSFUNCTION | ICOS CORPORATION (US) | 2000-03-28 | — | — | US | disclosed |
| EP-0912567-A1 | CARBOLINE DERIVATIVES | ICOS CORPORATION (US) | 1999-05-06 | — | — | EP | disclosed |
| WO-1997043287-A1 | CARBOLINE DERIVATIVES | ICOS CORPORATION (US) | 1997-11-20 | — | — | WO | disclosed |
| US-5478851-A | Hyperglycemic agent and antilipemic agent | BEECHAM GROUP PLC (GB) | 1995-12-26 | — | — | US | disclosed |
| US-5478850-A | Treating hyperglycemia, hyperlipidemia, hypertension | BEECHAM GROUP PLC (GB) | 1995-12-26 | — | — | US | disclosed |
| EP-0555249-A1 | THIAZOLIDINEDIONE DERIVATIVES | BEECHAM GROUP plc (GB) | 1993-08-18 | — | — | EP | disclosed |
| EP-0555264-A1 | NOVEL COMPOUNDS | BEECHAM GROUP plc (GB) | 1993-08-18 | — | — | EP | disclosed |
| WO-1992007850-A1 | NOVEL COMPOUNDS | BEECHAM GROUP PLC (GB) | 1992-05-14 | — | — | WO | disclosed |
| WO-1992007839-A1 | THIAZOLIDINEDIONE DERIVATIVES | BEECHAM GROUP PLC (GB) | 1992-05-14 | — | — | WO | disclosed |