Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RY2 | P41231 | 11/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.36 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | PRNP | P04156 | 1/20 | 0.33 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.33 |
| ▸ | USP2 | O75604 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7492915 | 0.91 | P2RY2 (0.49) | P2RY2KDM4EPRNPRXFP1 | |
| SCHEMBL7487605 | 0.82 | P2RY2 (0.40) | P2RY2ALDH1A1HPGDALOX15ALOX12 | |
| SCHEMBL7491790 | 0.81 | P2RY2 (0.47) | P2RY2ALDH1A1HPGDALOX15ALOX12 | |
| SCHEMBL7493681 | 0.78 | P2RY2 (0.43) | P2RY2ALDH1A1KDM4E | |
| SCHEMBL7486881 | 0.74 | P2RY2 (0.38) | P2RY2 | |
| SCHEMBL7488855 | 0.72 | P2RY2 (0.49) | P2RY2ALOX15 | |
| SCHEMBL7489807 | 0.72 | P2RY2 (0.47) | P2RY2 | |
| SCHEMBL7594879 | 0.71 | P2RY2 (0.51) | P2RY2ALDH1A1KDM4EL3MBTL1 | |
| SCHEMBL7488052 | 0.68 | P2RY2 (0.44) | P2RY2 | |
| SCHEMBL7492589 | 0.66 | P2RY2 (0.40) | P2RY2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0996617-B1 | 2,4-Dithi(oxo)-pyridin-5-yl compounds bearing a tricyclic substituent useful as P2 purinoceptor antagonists | ASTRAZENECA AB (SE) | 2002-01-09 | — | — | EP | disclosed |
| US-6107297-A | 2,4-Dithi(oxo)-pyrimidin-5-yl compounds bearing a tricyclic substituent useful as P2 purinoceptor antagonists | ASTRA PHARMACEUTICALS LIMITED (GB) | 2000-08-22 | — | — | US | disclosed |