Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RY2 | P41231 | 11/20 | 0.47 |
| ▸ | LCK | P06239 | 1/20 | 0.33 |
| ▸ | MKNK2 | Q9HBH9 | 2/20 | 0.33 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.33 |
| ▸ | JUN | P05412 | 1/20 | 0.32 |
| ▸ | CDK2 | P24941 | 1/20 | 0.32 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.32 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.32 |
| ▸ | IDH1 | O75874 | 4/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7486664 | 0.91 | P2RY2 (0.50) | P2RY2 | |
| SCHEMBL7491790 | 0.81 | P2RY2 (0.47) | P2RY2 | |
| SCHEMBL7488052 | 0.79 | P2RY2 (0.44) | P2RY2 | |
| SCHEMBL7489113 | 0.79 | P2RY2 (0.51) | P2RY2 | |
| SCHEMBL7485382 | 0.74 | P2RY2 (0.51) | P2RY2 | |
| SCHEMBL7488855 | 0.73 | P2RY2 (0.49) | P2RY2 | |
| SCHEMBL7490022 | 0.72 | P2RY2 (0.46) | P2RY2 | |
| SCHEMBL7486167 | 0.71 | P2RY2 (0.47) | P2RY2 | |
| SCHEMBL7491112 | 0.70 | P2RY2 (0.49) | P2RY2 | |
| SCHEMBL7594879 | 0.69 | P2RY2 (0.51) | P2RY2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0996617-B1 | 2,4-Dithi(oxo)-pyridin-5-yl compounds bearing a tricyclic substituent useful as P2 purinoceptor antagonists | ASTRAZENECA AB (SE) | 2002-01-09 | — | — | EP | disclosed |
| US-6107297-A | 2,4-Dithi(oxo)-pyrimidin-5-yl compounds bearing a tricyclic substituent useful as P2 purinoceptor antagonists | ASTRA PHARMACEUTICALS LIMITED (GB) | 2000-08-22 | — | — | US | disclosed |