Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 1/20 | 0.58 |
| ▸ | RAB9A | P51151 | 1/20 | 0.58 |
| ▸ | SUCNR1 | Q9BXA5 | 8/20 | 0.57 |
| ▸ | ITGB3 | P05106 | 2/20 | 0.55 |
| ▸ | ITGA2B | P08514 | 2/20 | 0.55 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.53 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.53 |
| ▸ | POLB | P06746 | 1/20 | 0.53 |
| ▸ | MAPT | P10636 | 1/20 | 0.53 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.53 |
| ▸ | CA12 | O43570 | 2/20 | 0.50 |
| ▸ | CA1 | P00915 | 2/20 | 0.50 |
| ▸ | CA2 | P00918 | 2/20 | 0.50 |
| ▸ | CA9 | Q16790 | 2/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7490606 | 0.88 | ITGB3 (0.64) | SUCNR1ITGB3ITGA2BPOLBMAPT | |
| SCHEMBL7296988 | 0.87 | ITGB3 (0.62) | SUCNR1ITGB3ITGA2BPOLBMAPT | |
| SCHEMBL7361860 | 0.86 | CA1 (0.55) | SUCNR1ITGB3ITGA2BPOLBMAPT | |
| SCHEMBL20024957 | 0.86 | ITGB1 (0.59) | SUCNR1ITGB3ITGA2BCA12CA1 | |
| SCHEMBL7488523 | 0.83 | CA12 (0.56) | SUCNR1ITGB3ITGA2BPOLBCA12 | |
| SCHEMBL7291185 | 0.83 | ITGB3 (0.58) | SUCNR1ITGB3ITGA2BPAX8TDP1 | |
| SCHEMBL29260893 | 0.82 | ITGB3 (0.66) | ITGB3ITGA2BPOLBMAPTMAPK1 | |
| SCHEMBL7490286 | 0.81 | GAA (0.60) | GAARAB9AITGB3ITGA2BMEN1 | |
| SCHEMBL7490295 | 0.81 | GAA (0.60) | GAARAB9AITGB3ITGA2BMEN1 | |
| SCHEMBL9161400 | 0.80 | ITGB3 (0.72) | SUCNR1ITGB3ITGA2BPOLBMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0760658-B1 | COMPOUNDS FOR INHIBITING OSTEOCLAST-MEDIATED BONE RESORPTION | MERCK & CO INC (US) | 2002-11-13 | — | — | EP | disclosed |
| US-5741796-A | Pyridyl and naphthyridyl compounds for inhibiting osteoclast-mediated bone resorption | MERCK & CO., INC. (US) | 1998-04-21 | — | — | US | disclosed |
| EP-0760658-A4 | COMPOUNDS FOR INHIBITING OSTEOCLAST-MEDIATED BONE RESORPTION | MERCK & CO INC (US) | 1997-09-17 | — | — | EP | disclosed |
| EP-0760658-A1 | COMPOUNDS FOR INHIBITING OSTEOCLAST-MEDIATED BONE RESORPTION | MERCK & CO. INC. (US) | 1997-03-12 | — | — | EP | disclosed |
| WO-1995032710-A1 | COMPOUNDS FOR INHIBITING OSTEOCLAST-MEDIATED BONE RESORPTION | MERCK & CO., INC. (US) | 1995-12-07 | — | — | WO | disclosed |