Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITGB3 | P05106 | 14/20 | 0.64 |
| ▸ | ITGA2B | P08514 | 14/20 | 0.64 |
| ▸ | POLB | P06746 | 1/20 | 0.56 |
| ▸ | MAPT | P10636 | 1/20 | 0.56 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.56 |
| ▸ | ITGAV | P06756 | 1/20 | 0.54 |
| ▸ | SUCNR1 | Q9BXA5 | 3/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7296988 | 0.99 | ITGB3 (0.62) | ITGB3ITGA2BPOLBMAPTMAPK1 | |
| SCHEMBL29260893 | 0.94 | ITGB3 (0.66) | ITGB3ITGA2BPOLBMAPTMAPK1 | |
| SCHEMBL9161400 | 0.93 | ITGB3 (0.72) | ITGB3ITGA2BPOLBMAPTMAPK1 | |
| SCHEMBL7402776 | 0.93 | ITGB3 (0.72) | ITGB3ITGA2BPOLBMAPTMAPK1 | |
| SCHEMBL30638155 | 0.91 | ITGB3 (0.63) | ITGB3ITGA2BPOLBMAPTMAPK1 | |
| SCHEMBL30149863 | 0.90 | ITGB3 (0.67) | ITGB3ITGA2BPOLBMAPTMAPK1 | |
| SCHEMBL25389246 | 0.89 | ITGB3 (0.51) | ITGB3ITGA2BPOLBMAPTMAPK1 | |
| SCHEMBL25389248 | 0.89 | ITGB3 (0.51) | ITGB3ITGA2BPOLBMAPTMAPK1 | |
| SCHEMBL7490231 | 0.88 | GAA (0.58) | ITGB3ITGA2BPOLBMAPTMAPK1 | |
| SCHEMBL6716140 | 0.88 | ITGB3 (0.75) | ITGB3ITGA2BMAPTITGAV |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0760658-B1 | COMPOUNDS FOR INHIBITING OSTEOCLAST-MEDIATED BONE RESORPTION | MERCK & CO INC (US) | 2002-11-13 | — | — | EP | disclosed |
| US-5929120-A | Guainidino, formamidino, amino and related compounds for inhibiting osteoclast-mediated bone resorption | MERCK & CO., INC. (US) | 1999-07-27 | — | — | US | disclosed |
| US-5741796-A | Pyridyl and naphthyridyl compounds for inhibiting osteoclast-mediated bone resorption | MERCK & CO., INC. (US) | 1998-04-21 | — | — | US | disclosed |