Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3827331 | 0.89 | HTR6 (0.40) | HTR6HPGDKMT2ASMN1; SMN2 | |
| SCHEMBL3827330 | 0.89 | HTR6 (0.40) | HTR6HPGDKMT2ASMN1; SMN2 | |
| SCHEMBL21920952 | 0.89 | HTR6 (0.40) | HTR6HPGDKMT2ASMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL21852645 | 0.86 | HPGD (0.39) | HTR6HPGDKMT2ASMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL20595109 | 0.86 | HPGD (0.39) | HTR6HPGDKMT2ASMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL21852697 | 0.86 | HPGD (0.39) | HTR6HPGDKMT2ASMN1; SMN2 | |
| SCHEMBL24379445 | 0.74 | LMNA (0.43) | HTR6HPGDKMT2ASMN1; SMN2 | |
| SCHEMBL22692239 | 0.74 | LMNA (0.43) | HTR6HPGDKMT2ASMN1; SMN2 | |
| SCHEMBL7897450 | 0.73 | HPGD (0.47) | HTR6HPGDKMT2ASMN1; SMN2 | |
| SCHEMBL22834986 | 0.73 | HPGD (0.47) | HTR6HPGDKMT2ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0882044-B1 | 1,4-DIHYDROPYRIDINE COMPOUNDS AS BRADYKININ ANTAGONISTS | PFIZER (US) | 2002-07-17 | — | — | EP | disclosed |
| US-6131226-A | 2-SUBSTITUTED,3,5-BIS(METHOXYCARBONYL),4-(2,6-DIHALOPHENYL), 6-(1-((SUBSTITUTED)RING)PIPERAZIN-1,4-YLENE-CARBONYLMETHYL)-1, 4-DIHYDROPYRIDINES; FOR TREATING INFLAMMATION, PAIN, VIRAL INFECTIONS, CARDIOVASCULAR DISEASE, ALLERGIES, ASTHMA | PFIZER INC. (US) | 2000-10-17 | — | — | US | disclosed |