Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.41 |
| ▸ | DRD2 | P14416 | 2/20 | 0.40 |
| ▸ | ESR1 | P03372 | 4/20 | 0.36 |
| ▸ | ESR2 | Q92731 | 3/20 | 0.36 |
| ▸ | USP7 | Q93009 | 1/20 | 0.36 |
| ▸ | DRD1 | P21728 | 1/20 | 0.36 |
| ▸ | DPP4 | P27487 | 1/20 | 0.35 |
| ▸ | OPRM1 | P35372 | 4/20 | 0.33 |
| ▸ | OPRD1 | P41143 | 2/20 | 0.33 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.33 |
| ▸ | PRKAB2 | O43741 | 1/20 | 0.33 |
| ▸ | PRKAG1 | P54619 | 1/20 | 0.33 |
| ▸ | PRKAA2 | P54646 | 1/20 | 0.33 |
| ▸ | PRKAA1 | Q13131 | 1/20 | 0.33 |
| ▸ | PRKAG3 | Q9UGI9 | 1/20 | 0.33 |
| ▸ | PRKAG2 | Q9UGJ0 | 1/20 | 0.33 |
| ▸ | PRKAB1 | Q9Y478 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1513363 | 0.84 | SIGMAR1 (0.46) | SIGMAR1DRD2DPP4PRKAB2PRKAG1 | |
| SCHEMBL1513458 | 0.81 | DRD2 (0.54) | SIGMAR1DRD2PRKAB2PRKAG1PRKAA2 | |
| SCHEMBL30232423 | 0.81 | DRD2 (0.54) | SIGMAR1DRD2PRKAB2PRKAG1PRKAA2 | |
| Hydrochloric Acid SCHEMBL29995041 | 0.80 | DRD2 (0.53) | SIGMAR1DRD2PRKAB2PRKAG1PRKAA2 | |
| SCHEMBL750271 | 0.79 | SIGMAR1 (0.45) | SIGMAR1DRD2ESR1ESR2DRD1 | |
| SCHEMBL615903 | 0.77 | SIGMAR1 (0.57) | SIGMAR1DRD2OPRM1OPRD1OPRK1 | |
| SCHEMBL7510607 | 0.75 | DRD2 (0.46) | SIGMAR1DRD2DPP4OPRM1OPRD1 | |
| SCHEMBL3108178 | 0.75 | CCNT1 (0.40) | SIGMAR1DRD2DPP4 | |
| Ethyne SCHEMBL27599449 | 0.74 | SIGMAR1 (0.54) | SIGMAR1DRD2OPRM1OPRD1OPRK1 | |
| SCHEMBL2271940 | 0.71 | SIGMAR1 (0.44) | SIGMAR1DRD2DPP4OPRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102482280-A | [1,2,4] triazolo [4,3-b ] pyridazines as ligands for androgen receptors | ASTRAZENECA AB | 2012-05-30 | — | — | CN | disclosed |
| EP-2430024-A1 | [1,2,4]TRIAZOLO [4,3-B]PYRIDAZINES AS LIGANDS OF THE ANDROGEN RECEPTOR | AstraZeneca AB (SE) | 2012-03-21 | — | — | EP | disclosed |
| WO-2010131022-A1 | [1,2,4] TRIAZOLO [4,3-B] PYRIDAZINES AS LIGANDS OF THE ANDROGEN RECEPTOR | ASTRAZENECA AB (SE) | 2010-11-18 | — | — | WO | disclosed |
| US-20100292222-A1 | CHEMICAL COMPOUNDS 751 | ASTRAZENECA AB (SE) | 2010-11-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100292222-A1 | CHEMICAL COMPOUNDS 751 | AR, NR5A1, KLK3 | SIGMAR1 518/4885DRD2 1236/4885ESR1 23/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.