Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 6/20 | 0.59 |
| ▸ | AKR1C3 | P42330 | 2/20 | 0.48 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.45 |
| ▸ | PKM | P14618 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4674250 | 0.88 | HTR6 (0.77) | HTR6SLC6A4 | |
| SCHEMBL7490788 | 0.88 | HTR6 (0.56) | HTR6AKR1C3SLC6A4AKR1C2KMT2A | |
| SCHEMBL7479822 | 0.86 | HTR6 (0.80) | HTR6SLC6A4KMT2A | |
| SCHEMBL7490243 | 0.86 | HTR6 (0.56) | HTR6AKR1C3SLC6A4AKR1C2KMT2A | |
| SCHEMBL7485121 | 0.84 | HTR6 (0.54) | HTR6AKR1C3SLC6A4AKR1C2 | |
| SCHEMBL7483235 | 0.83 | HTR6 (0.53) | HTR6AKR1C3SLC6A4 | |
| SCHEMBL7485130 | 0.83 | HTR6 (0.59) | HTR6SLC6A4KMT2A | |
| SCHEMBL7482946 | 0.83 | HTR6 (0.59) | HTR6AKR1C3SLC6A4 | |
| SCHEMBL7868014 | 0.82 | HTR6 (0.56) | HTR6SLC6A4 | |
| SCHEMBL7484100 | 0.82 | HTR6 (0.54) | HTR6SLC6A4SMN1; SMN2KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1173432-A1 | PIPERIDINE-INDOLE COMPOUNDS HAVING 5-HT6 AFFINITY | NPS Allelix Corp. (CA) | 2002-01-23 | — | — | EP | claimed |
| WO-2000063203-A1 | PIPERIDINE-INDOLE COMPOUNDS HAVING 5-HT6 AFFINITY | ALLELIX BIOPHARMACEUTICALS INC. (CA) | 2000-10-26 | — | — | WO | claimed |
| EP-1173432-A1 | PIPERIDINE-INDOLE COMPOUNDS HAVING 5-HT6 AFFINITY | NPS Allelix Corp. (CA) | 2002-01-23 | — | — | EP | disclosed |
| WO-2000063203-A1 | PIPERIDINE-INDOLE COMPOUNDS HAVING 5-HT6 AFFINITY | ALLELIX BIOPHARMACEUTICALS INC. (CA) | 2000-10-26 | — | — | WO | disclosed |
| US-6133287-A | SEROTONIN 5-HT6 RECEPTOR ANTAGONISTS; CENTRAL NERVOUS SYSTEM DISORDERS, E.G., PSYCHOSIS, SCHIZOPHRENIA, MANIC DEPRESSION, DEPRESSION, MEMORY DISTURBANCES, PARKINSONISM, AMYLOTROPHIC LATERAL SCLEROSIS, ALZHEIMER'S AND HUNTINGTON'S DISEASE | ALLELIX BIOPHARMACEUTICALS INC. (CA) | 2000-10-17 | — | — | US | disclosed |