Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.68 |
| ▸ | GRIN1 | Q05586 | 2/20 | 0.68 |
| ▸ | GRIN2A | Q12879 | 2/20 | 0.68 |
| ▸ | GRIN2B | Q13224 | 2/20 | 0.68 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.68 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.68 |
| ▸ | CYP2B6 | P20813 | 1/20 | 0.68 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.68 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.68 |
| ▸ | PRCP | P42785 | 1/20 | 0.68 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.68 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.68 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.68 |
| ▸ | GRIN3A | Q8TCU5 | 1/20 | 0.68 |
| ▸ | OPRM1 | P35372 | 8/20 | 0.66 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.66 |
| ▸ | SLC6A9 | P48067 | 9/20 | 0.52 |
| ▸ | OPRL1 | P41146 | 2/20 | 0.52 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7489860 | 0.98 | GRIN1 (0.71) | SIGMAR1GRIN1GRIN2AGRIN2BGRIN2D | |
| SCHEMBL7095191 | 0.98 | GRIN1 (0.71) | SIGMAR1GRIN1GRIN2AGRIN2BGRIN2D | |
| SCHEMBL7493298 | 0.98 | GRIN1 (0.71) | SIGMAR1GRIN1GRIN2AGRIN2BGRIN2D | |
| SCHEMBL7493886 | 0.93 | SIGMAR1 (0.56) | SIGMAR1GRIN1GRIN2AGRIN2BGRIN2D | |
| SCHEMBL2203974 | 0.86 | GRIN1 (0.68) | SIGMAR1GRIN1GRIN2AGRIN2BGRIN2D | |
| SCHEMBL733277 | 0.86 | GRIN1 (0.62) | SIGMAR1GRIN1GRIN2AGRIN2BGRIN2D | |
| SCHEMBL9431836 | 0.84 | GRIN1 (0.71) | SIGMAR1GRIN1GRIN2AGRIN2BGRIN2D | |
| Ethylene SCHEMBL11093647 | 0.83 | GRIN1 (0.64) | SIGMAR1GRIN1GRIN2AGRIN2BGRIN2D | |
| Rolicyclidine SCHEMBL517928 | 0.81 | SIGMAR1 (1.00) | SIGMAR1GRIN1GRIN2AGRIN2BGRIN2D | |
| SCHEMBL9153279 | 0.81 | SIGMAR1 (1.00) | SIGMAR1GRIN1GRIN2AGRIN2BGRIN2D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6423725-B1 | ANALGESICS | PFIZER INC | 2002-07-23 | — | — | US | disclosed |
| EP-1049689-B1 | 4-(2-KETO-1-BENZIMIDAZOLINYL)PIPERIDINE COMPOUNDS AS ORL1-RECEPTOR AGONISTS | PFIZER (US) | 2002-06-26 | — | — | EP | disclosed |
| EP-1049689-A1 | 4-(2-KETO-1-BENZIMIDAZOLINYL)PIPERIDINE COMPOUNDS AS ORL1-RECEPTOR AGONISTS | PFIZER INC. (US) | 2000-11-08 | — | — | EP | disclosed |
| WO-1999036421-A1 | 4-(2-KETO-1-BENZIMIDAZOLINYL)PIPERIDINE COMPOUNDS AS ORL1-RECEPTOR AGONISTS | PFIZER PHARMACEUTICALS INC. (JP) | 1999-07-22 | — | — | WO | disclosed |