Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIN1 | Q05586 | 4/20 | 0.71 |
| ▸ | GRIN2A | Q12879 | 4/20 | 0.71 |
| ▸ | GRIN2B | Q13224 | 3/20 | 0.71 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.71 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.71 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.71 |
| ▸ | CYP2B6 | P20813 | 1/20 | 0.71 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.71 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.71 |
| ▸ | PRCP | P42785 | 1/20 | 0.71 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.71 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.71 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.71 |
| ▸ | GRIN3A | Q8TCU5 | 1/20 | 0.71 |
| ▸ | OPRM1 | P35372 | 7/20 | 0.69 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.69 |
| ▸ | SLC6A9 | P48067 | 7/20 | 0.55 |
| ▸ | OPRL1 | P41146 | 2/20 | 0.55 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7489860 | 1.00 | GRIN1 (0.71) | GRIN1GRIN2AGRIN2BSIGMAR1GRIN2D | |
| SCHEMBL7493298 | 1.00 | GRIN1 (0.71) | GRIN1GRIN2AGRIN2BSIGMAR1GRIN2D | |
| SCHEMBL7490969 | 0.98 | SIGMAR1 (0.68) | GRIN1GRIN2AGRIN2BSIGMAR1GRIN2D | |
| SCHEMBL7493886 | 0.91 | SIGMAR1 (0.56) | GRIN1GRIN2AGRIN2BSIGMAR1GRIN2D | |
| SCHEMBL9431836 | 0.86 | GRIN1 (0.71) | GRIN1GRIN2AGRIN2BSIGMAR1GRIN2D | |
| SCHEMBL733277 | 0.84 | GRIN1 (0.62) | GRIN1GRIN2AGRIN2BSIGMAR1GRIN2D | |
| SCHEMBL2203974 | 0.84 | GRIN1 (0.68) | GRIN1GRIN2AGRIN2BSIGMAR1GRIN2D | |
| SCHEMBL9153279 | 0.83 | SIGMAR1 (1.00) | GRIN1GRIN2AGRIN2BSIGMAR1GRIN2D | |
| Rolicyclidine SCHEMBL517928 | 0.83 | SIGMAR1 (1.00) | GRIN1GRIN2AGRIN2BSIGMAR1GRIN2D | |
| SCHEMBL3407261 | 0.83 | GRIN1 (0.92) | GRIN1GRIN2AGRIN2BSIGMAR1GRIN2D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20030109549-A1 | 2-Substituted-1-piperidyl benzimidazole compounds as ORL1-receptor agonists | ITO FUMITAKA (JP) | 2003-06-12 | — | — | US | disclosed |
| EP-1102762-B1 | 2-SUBSTITUTED-1-PIPERIDYL BENZIMIDAZOLE COMPOUNDS AS ORL1-RECEPTOR AGONISTS | PFIZER (US) | 2002-11-13 | — | — | EP | disclosed |
| US-6423725-B1 | ANALGESICS | PFIZER INC | 2002-07-23 | — | — | US | disclosed |
| EP-1049689-B1 | 4-(2-KETO-1-BENZIMIDAZOLINYL)PIPERIDINE COMPOUNDS AS ORL1-RECEPTOR AGONISTS | PFIZER (US) | 2002-06-26 | — | — | EP | disclosed |
| EP-1102762-A2 | 2-SUBSTITUTED-1-PIPERIDYL BENZIMIDAZOLE COMPOUNDS AS ORL1-RECEPTOR AGONISTS | PFIZER INC. (US) | 2001-05-30 | — | — | EP | disclosed |
| US-6172067-B1 | ANALGESICS, ANTIINFLAMMATORY AGENTS | PFIZER INC. | 2001-01-09 | — | — | US | disclosed |
| EP-1049689-A1 | 4-(2-KETO-1-BENZIMIDAZOLINYL)PIPERIDINE COMPOUNDS AS ORL1-RECEPTOR AGONISTS | PFIZER INC. (US) | 2000-11-08 | — | — | EP | disclosed |
| WO-2000008013-A2 | 2-SUBSTITUTED-1-PIPERIDYL BENZIMIDAZOLE COMPOUNDS AS ORL1-RECEPTOR AGONISTS | PFIZER PHARMACEUTICALS INC. (JP) | 2000-02-17 | — | — | WO | disclosed |
| WO-1999036421-A1 | 4-(2-KETO-1-BENZIMIDAZOLINYL)PIPERIDINE COMPOUNDS AS ORL1-RECEPTOR AGONISTS | PFIZER PHARMACEUTICALS INC. (JP) | 1999-07-22 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030109549-A1 | 2-Substituted-1-piperidyl benzimidazole compounds as ORL1-receptor agonists | OPRL1, ORMDL3, OPRM1 | GRIN1 138/4885GRIN2A 557/4885GRIN2B 649/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.