Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALPL | P05186 | 1/20 | 0.38 |
| ▸ | CA1 | P00915 | 1/20 | 0.35 |
| ▸ | CA2 | P00918 | 1/20 | 0.35 |
| ▸ | PDE4A | P27815 | 3/20 | 0.35 |
| ▸ | PDE4C | Q08493 | 3/20 | 0.35 |
| ▸ | PDE4D | Q08499 | 3/20 | 0.35 |
| ▸ | CYSLTR2 | Q9NS75 | 1/20 | 0.35 |
| ▸ | CYSLTR1 | Q9Y271 | 1/20 | 0.35 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.34 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.33 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.33 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.33 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.33 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | GPR3 | P46089 | 1/20 | 0.33 |
| ▸ | EGFR | P00533 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.33 |
| ▸ | FDPS | P14324 | 1/20 | 0.32 |
| ▸ | DRD2 | P14416 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16225036 | 0.76 | PDE4A (0.34) | CA1CA2PDE4APDE4CPDE4D | |
| SCHEMBL2708721 | 0.75 | ALPL (0.49) | ALPLCA1CA2SLC22A12CYP1A2 | |
| SCHEMBL4753618 | 0.75 | ALPL (0.39) | ALPLADRA2ANPY5RMCHR1KDM4E | |
| SCHEMBL30904613 | 0.75 | ALPL (0.39) | ALPLADRA2ANPY5RMCHR1KDM4E | |
| SCHEMBL29461538 | 0.74 | MGAM (0.40) | CA1CA2PDE4APDE4CPDE4D | |
| SCHEMBL244946 | 0.74 | MGAM (0.40) | CA1CA2PDE4APDE4CPDE4D | |
| SCHEMBL15110631 | 0.73 | HTT (0.51) | ALPLKDM4ECYP1A2ALDH1A1LMNA | |
| SCHEMBL127875 | 0.73 | PDE4A (0.46) | ALPLCA1CA2PDE4APDE4C | |
| SCHEMBL30808338 | 0.72 | LMNA (0.42) | CYSLTR2CYSLTR1KDM4EGPR3EGFR | |
| SCHEMBL6614036 | 0.72 | CNR2 (0.35) | KDM4EGPR3EGFRCYP1A2FDPS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1218354-A1 | QUINAZOLINE DERIVATIVES AND THEIR USE AS PHARMACEUTICALS | AstraZeneca AB (SE) | 2002-07-03 | — | — | EP | disclosed |
| WO-2001021596-A1 | QUINAZOLINE DERIVATIVES AND THEIR USE AS PHARMACEUTICALS | ASTRAZENECA AB (SE) | 2001-03-29 | — | — | WO | disclosed |