Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.41 |
| ▸ | ADORA2B | P29275 | 2/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | GLA | P06280 | 1/20 | 0.41 |
| ▸ | GSK3B | P49841 | 3/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | ACVRL1 | P37023 | 1/20 | 0.40 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.40 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | ABL1 | P00519 | 3/20 | 0.39 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.39 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.39 |
| ▸ | GSK3A | P49840 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7498207 | 0.75 | KMT2A (0.36) | HPGDKMT2AALDH1A1ABL1RXFP1 | |
| SCHEMBL9450207 | 0.75 | RECQL (0.35) | ROCK2ROCK1ALDH1A1 | |
| SCHEMBL9449822 | 0.72 | ALDH1A1 (0.37) | SMN1; SMN2ALDH1A1ABL1 | |
| SCHEMBL1921108 | 0.72 | GAA (0.49) | HPGDADORA2AGLAKMT2ASMN1; SMN2 | |
| SCHEMBL4979085 | 0.70 | KMT2A (0.57) | HPGDADORA2AADORA2BCYP3A4CYP2D6 | |
| SCHEMBL12470673 | 0.69 | AOC1 (0.37) | GSK3BKMT2AROCK2ROCK1 | |
| Hydrochloric Acid SCHEMBL27769986 | 0.69 | KMT2A (0.56) | HPGDADORA2AADORA2BCYP3A4CYP2D6 | |
| SCHEMBL18038519 | 0.68 | GSK3A (0.67) | HPGDGSK3BKMT2ASMN1; SMN2DYRK1A | |
| SCHEMBL3769622 | 0.67 | HPGD (0.56) | HPGDADORA2ASMN1; SMN2ALDH1A1 | |
| SCHEMBL7044143 | 0.67 | HPGD (0.51) | HPGDADORA2AKMT2ASMN1; SMN2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0785789-B1 | DIAZEPINO-INDOLES AS PHOSPHODIESTERASE IV INHIBITORS | PFIZER (FR) | 2002-09-11 | — | — | EP | disclosed |
| EP-0785789-A1 | DIAZEPINO-INDOLES AS PHOSPHODIESTERASE IV INHIBITORS | INSTITUT DE RECHERCHE JOUVEINAL (I.R.J) (FR) | 1997-07-30 | — | — | EP | disclosed |
| WO-1996011690-A1 | DIAZEPINO-INDOLES AS PHOSPHODIESTERASE IV INHIBITORS | INSTITUT DE RECHERCHE JOUVEINAL (FR) | 1996-04-25 | — | — | WO | disclosed |