Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.60 |
| ▸ | ALPL | P05186 | 8/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.55 |
| ▸ | HPGD | P15428 | 2/20 | 0.52 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.52 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.52 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.52 |
| ▸ | TSHR | P16473 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | GSK3A | P49840 | 1/20 | 0.32 |
| ▸ | GSK3B | P49841 | 1/20 | 0.32 |
| ▸ | GLA | P06280 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19398370 | 0.81 | HSD17B10 (0.70) | HSD17B10ALPLALDH1A1HPGDCYP3A4 | |
| SCHEMBL7486185 | 0.77 | HCAR2 (0.43) | HSD17B10ALPLALDH1A1 | |
| SCHEMBL460286 | 0.68 | HSD17B10 (0.63) | HSD17B10ALPLALDH1A1HPGDCYP3A4 | |
| SCHEMBL10123130 | 0.67 | HSD17B10 (0.61) | HSD17B10ALPLALDH1A1HPGDCYP3A4 | |
| SCHEMBL1218889 | 0.66 | HSD17B10 (0.56) | HSD17B10ALPLALDH1A1HPGDCYP3A4 | |
| SCHEMBL7482798 | 0.66 | ALPL (0.67) | HSD17B10ALPLALDH1A1HPGDCYP3A4 | |
| SCHEMBL7487043 | 0.65 | ALPL (0.66) | HSD17B10ALPLALDH1A1HPGDCYP3A4 | |
| SCHEMBL13343014 | 0.64 | HSD17B10 (0.58) | HSD17B10ALPLALDH1A1HPGDCYP3A4 | |
| SCHEMBL7482231 | 0.64 | HSD17B10 (0.58) | HSD17B10ALPLALDH1A1HPGDCYP3A4 | |
| SCHEMBL1220143 | 0.63 | HSD17B10 (0.56) | HSD17B10ALPLALDH1A1HPGDCYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1177185-A1 | 4, 5, 6, 7-TETRAHYDROINDAZOLE DERIVATIVES AS ANTITUMOR AGENTS | PHARMACIA & UPJOHN S.p.A. (IT) | 2002-02-06 | — | — | EP | disclosed |
| WO-2000069846-A1 | 4,5,6,7-TETRAHYDROINDAZOLE DERIVATIVES AS ANTITUMOR AGENTS | PHARMACIA & UPJOHN S.P.A. (IT) | 2000-11-23 | — | — | WO | disclosed |