Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | MAPT | P10636 | 3/20 | 0.41 |
| ▸ | THRB | P10828 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.39 |
| ▸ | HPGD | P15428 | 2/20 | 0.39 |
| ▸ | RAB9A | P51151 | 2/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | PTGS2 | P35354 | 6/20 | 0.38 |
| ▸ | PTGS1 | P23219 | 5/20 | 0.38 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.36 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.36 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.36 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7490468 | 0.80 | MEN1 (0.40) | SMN1; SMN2ALDH1A1MAPTTHRBTDP1 | |
| SCHEMBL6164472 | 0.79 | ALDH1A1 (0.48) | SMN1; SMN2ALDH1A1MAPTTHRBTDP1 | |
| SCHEMBL13889376 | 0.75 | SMN1; SMN2 (0.41) | SMN1; SMN2ALDH1A1MAPTTHRBTDP1 | |
| SCHEMBL6163369 | 0.69 | CCNA2 (0.47) | SMN1; SMN2ALDH1A1MAPTTHRBTDP1 | |
| SCHEMBL6167069 | 0.69 | CCNA2 (0.47) | SMN1; SMN2ALDH1A1MAPTTHRBTDP1 | |
| SCHEMBL6163901 | 0.69 | SMN1; SMN2 (0.46) | SMN1; SMN2ALDH1A1MAPTTHRBTDP1 | |
| SCHEMBL22349773 | 0.67 | DHODH (0.44) | ALDH1A1MAPTTDP1KDM4EHPGD | |
| SCHEMBL29871089 | 0.67 | GABRA1 (0.44) | SMN1; SMN2ALDH1A1MAPTTHRBTDP1 | |
| SCHEMBL4971846 | 0.67 | GABRA1 (0.44) | SMN1; SMN2ALDH1A1MAPTTHRBTDP1 | |
| SCHEMBL17051109 | 0.67 | POLB (0.36) | SMN1; SMN2ALDH1A1MAPTTDP1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1177185-A1 | 4, 5, 6, 7-TETRAHYDROINDAZOLE DERIVATIVES AS ANTITUMOR AGENTS | PHARMACIA & UPJOHN S.p.A. (IT) | 2002-02-06 | — | — | EP | disclosed |
| WO-2000069846-A1 | 4,5,6,7-TETRAHYDROINDAZOLE DERIVATIVES AS ANTITUMOR AGENTS | PHARMACIA & UPJOHN S.P.A. (IT) | 2000-11-23 | — | — | WO | disclosed |