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Morphine

Morphine

SCHEMBL7492942

CC(CCCCCCCC(=O)O)C(=O)O.CN1CC[C@]23c4c5ccc(O)c4O[C@H]2[C@@H](O)C=C[C@H]3[C@H]1C5.CN1CC[C@]23c4c5ccc(O)c4O[C@H]2[C@@H](O)C=C[C@H]3[C@H]1C5

nearest known ligand 0.70

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

OPRM1

The experimentally established mechanism targets of Morphine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 7)

geneUniProtsupporting neighboursconfidence
▸ OPRM1 known ✓ P35372 6/20 0.70
▸ OPRD1 P41143 8/20 0.70
▸ OPRK1 P41145 5/20 0.70
▸ MRGPRX2 Q96LB1 2/20 0.70
▸ SLC22A1 O15245 1/20 0.70
▸ ADRA2A P08913 1/20 0.70
▸ ARRB1 P49407 1/20 0.70

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Morphine SCHEMBL3476234 0.90 OPRD1 (0.75) OPRD1OPRM1OPRK1MRGPRX2SLC22A1
Morphine SCHEMBL547919 0.88 OPRD1 (0.78) OPRD1OPRM1OPRK1MRGPRX2SLC22A1
Morphine SCHEMBL3477082 0.87 OPRD1 (0.85) OPRD1OPRM1OPRK1MRGPRX2SLC22A1
Morphine SCHEMBL548200 0.86 OPRD1 (0.84) OPRD1OPRM1OPRK1MRGPRX2SLC22A1
Morphine SCHEMBL6650507 0.86 OPRD1 (0.69) OPRD1OPRM1OPRK1MRGPRX2SLC22A1
Morphine SCHEMBL6650502 0.86 OPRD1 (0.69) OPRD1OPRM1OPRK1MRGPRX2SLC22A1
Morphine SCHEMBL16635671 0.85 OPRD1 (0.85) OPRD1OPRM1OPRK1MRGPRX2SLC22A1
Morphine SCHEMBL28246596 0.85 OPRD1 (0.81) OPRD1OPRM1OPRK1MRGPRX2SLC22A1
Morphine SCHEMBL40753 0.85 OPRD1 (0.84) OPRD1OPRM1OPRK1MRGPRX2SLC22A1
Morphine SCHEMBL40754 0.85 OPRD1 (0.84) OPRD1OPRM1OPRK1MRGPRX2SLC22A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1017696-B1 ACIDIC ADDITION SALTS OF MORPHINE ALKALOIDS AND THE APPLICATION THEREOF LOHMANN THERAPIE SYST LTS (DE) 2002-03-20 — — EP disclosed
EP-1017696-A1 ACIDIC ADDITION SALTS OF MORPHINE ALKALOIDS AND THE APPLICATION THEREOF LTS Lohmann Therapie-Systeme AG (DE) 2000-07-12 — — EP disclosed
WO-1999015528-A1 ACIDIC ADDITION SALTS OF MORPHINE ALKALOIDS AND THE APPLICATION THEREOF LTS LOHMANN THERAPIE-SYSTEME AG (DE) 1999-04-01 — — WO disclosed
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