Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Morphine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 known ✓ | P35372 | 7/20 | 0.69 |
| ▸ | OPRD1 | P41143 | 8/20 | 0.69 |
| ▸ | OPRK1 | P41145 | 6/20 | 0.69 |
| ▸ | MRGPRX2 | Q96LB1 | 2/20 | 0.69 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.69 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.69 |
| ▸ | ARRB1 | P49407 | 1/20 | 0.69 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Morphine SCHEMBL22234325 | 0.95 | OPRD1 (0.75) | OPRD1OPRM1OPRK1MRGPRX2SLC22A1 | |
| Morphine SCHEMBL3476234 | 0.95 | OPRD1 (0.75) | OPRD1OPRM1OPRK1MRGPRX2SLC22A1 | |
| Ethyl Oleate SCHEMBL6478097 | 0.91 | OPRD1 (0.65) | OPRD1OPRM1OPRK1MRGPRX2SLC22A1 | |
| Morphine SCHEMBL10835255 | 0.88 | OPRD1 (0.73) | OPRD1OPRM1OPRK1MRGPRX2SLC22A1 | |
| Morphine SCHEMBL16635671 | 0.86 | OPRD1 (0.85) | OPRD1OPRM1OPRK1MRGPRX2SLC22A1 | |
| SCHEMBL6650505 | 0.86 | OPRD1 (0.62) | OPRD1OPRM1OPRK1MRGPRX2SLC22A1 | |
| Morphine SCHEMBL7492942 | 0.86 | OPRD1 (0.70) | OPRD1OPRM1OPRK1MRGPRX2SLC22A1 | |
| Codeine SCHEMBL7775792 | 0.85 | OPRM1 (0.77) | OPRD1OPRM1OPRK1MRGPRX2SLC22A1 | |
| Codeine SCHEMBL3477475 | 0.85 | OPRM1 (0.77) | OPRD1OPRM1OPRK1MRGPRX2SLC22A1 | |
| Codeine SCHEMBL7770906 | 0.85 | OPRM1 (0.77) | OPRD1OPRM1OPRK1MRGPRX2SLC22A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 28 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0767663-B1 | COMPOSITION COMPRISING MORPHINE, POLYPYRROLIDONE AND A POLYALKYLENEOXIDE | ALZA CORP (US) | 2002-04-03 | — | — | EP | claimed |
| EP-0767663-A1 | COMPOSITION COMPRISING MORPHINE, POLYPYRROLIDONE AND A POLYALKYLENEOXIDE | ALZA CORPORATION (US) | 1997-04-16 | — | — | EP | claimed |
| US-5593695-A | Morphine therapy | ALZA CORPORATION (US) | 1997-01-14 | — | — | US | claimed |
| WO-1996000066-A1 | COMPOSITION COMPRISING MORPHINE, POLYPYRROLIDONE AND A POLYALKYLENEOXIDE | ALZA CORPORATION (US) | 1996-01-04 | — | — | WO | claimed |
| US-5460826-A | Morphine therapy | ALZA CORPORATION (US) | 1995-10-24 | — | — | US | claimed |
| EP-1476155-A2 | METHODS AND COMPOSITIONS FOR REDUCING THE DEVELOPMENT OF DRUG TOLERANCE AND/OR PHYSICAL DEPENDENCE | The Regents of The University of California (US) | 2004-11-17 | — | — | EP | disclosed |
| US-20040024005-A1 | Methods and compositions for reducing the development of drug tolerance and/or physical dependence | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA | 2004-02-05 | — | — | US | disclosed |
| WO-2003061594-A2 | METHODS AND COMPOSITIONS FOR REDUCING THE DEVELOPMENT OF DRUG TOLERANCE AND/OR PHYSICAL DEPENDENCE | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2003-07-31 | — | — | WO | disclosed |
| EP-0767663-B1 | COMPOSITION COMPRISING MORPHINE, POLYPYRROLIDONE AND A POLYALKYLENEOXIDE | ALZA CORP (US) | 2002-04-03 | — | — | EP | disclosed |
| EP-0705433-A4 | COMPOSITIONS AND METHODS FOR ANTI-ADDICTIVE NARCOTIC ANALGESIS ACIVITY SCREENING AND TREATMENTS | UNIV CALIFORNIA (US) | 2001-09-26 | — | — | EP | disclosed |
| US-6270979-B1 | Methods for anti-addictive narcotic analgesic treatments | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA | 2001-08-07 | — | — | US | disclosed |
| EP-0846265-A4 | METHODS FOR G PROTEIN COUPLED RECEPTOR ACTIVITY SCREENING | UNIV CALIFORNIA (US) | 2001-06-27 | — | — | EP | disclosed |
| EP-0643768-A1 | OLIGONUCLEOTIDE SEQUENCES AND TRANSGENIC ANIMALS TRANSFECTED THEREWITH HAVING REDUCED SENSITIVITY TO NARCOTIC ANALGESICS | DUZ PARTNERSHIP (US) | 1995-03-22 | — | — | EP | disclosed |
| WO-1995000848-A1 | COMPOSITIONS AND METHODS FOR ANTI-ADDICTIVE NARCOTIC ANALGESIS ACIVITY SCREENING AND TREATMENTS | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 1995-01-05 | — | — | WO | disclosed |
| WO-1993025217-A1 | DES-TYR DYNORPHIN ANALOGUES | DES-TYR DYNORPHIN PARTNERSHIP (US) | 1993-12-23 | — | — | WO | disclosed |
| WO-1993021309-A1 | OLIGONUCLEOTIDE SEQUENCES AND TRANSGENIC ANIMALS TRANSFECTED THEREWITH HAVING REDUCED SENSITIVITY TO NARCOTIC ANALGESICS | DUZ PARTNERSHIP (US) | 1993-10-28 | — | — | WO | disclosed |
| EP-0096592-B1 | DYNORPHIN AMIDE ANALOGS | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 1986-09-24 | — | — | EP | disclosed |
| US-4462941-A | PONTENTIATION OF NARCOTIC ANALGESICS IN TOLERANT HOSTS | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 1984-07-31 | — | — | US | disclosed |
| EP-0096592-A1 | Dynorphin amide analogs | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 1983-12-21 | — | — | EP | disclosed |
| US-4361553-A | ADMINISTERING TO HOST TOLERANT TO NARCOTIC ANALGESICS | REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 1982-11-30 | — | — | US | disclosed |