Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK1 | P06493 | 16/20 | 0.57 |
| ▸ | GSK3B | P49841 | 15/20 | 0.57 |
| ▸ | CCNB2 | O95067 | 14/20 | 0.57 |
| ▸ | CCNB1 | P14635 | 14/20 | 0.57 |
| ▸ | CCNB3 | Q8WWL7 | 14/20 | 0.57 |
| ▸ | CDK5 | Q00535 | 8/20 | 0.55 |
| ▸ | CDK5R1 | Q15078 | 8/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.55 |
| ▸ | MEN1 | O00255 | 1/20 | 0.55 |
| ▸ | CDC7 | O00311 | 1/20 | 0.55 |
| ▸ | PLK4 | O00444 | 1/20 | 0.55 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.55 |
| ▸ | AURKA | O14965 | 1/20 | 0.55 |
| ▸ | NPC1 | O15118 | 1/20 | 0.55 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.55 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.55 |
| ▸ | CCNT2 | O60583 | 1/20 | 0.55 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.55 |
| ▸ | GMNN | O75496 | 1/20 | 0.55 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7501195 | 0.85 | HSP90AA1 (0.55) | CDK1GSK3BCCNB2CCNB1CCNB3 | |
| SCHEMBL7500769 | 0.85 | GSK3B (0.46) | CDK1GSK3BCCNB2CCNB1CCNB3 | |
| SCHEMBL7492409 | 0.85 | GSK3B (0.55) | CDK1GSK3BCCNB2CCNB1CCNB3 | |
| SCHEMBL7498410 | 0.83 | CDK1 (0.56) | CDK1GSK3BCCNB2CCNB1CCNB3 | |
| SCHEMBL7503733 | 0.81 | CA1 (0.46) | CDK1GSK3BCCNB2CCNB1CCNB3 | |
| SCHEMBL7493665 | 0.80 | CA1 (0.50) | CDK1GSK3BCCNB2CCNB1CCNB3 | |
| Water SCHEMBL7500648 | 0.80 | CA1 (0.46) | CDK1GSK3BCCNB2CCNB1CCNB3 | |
| Water SCHEMBL7500646 | 0.80 | CA1 (0.46) | CDK1GSK3BCCNB2CCNB1CCNB3 | |
| SCHEMBL7504955 | 0.79 | MPL (0.42) | CDK1GSK3BCCNB2CCNB1CCNB3 | |
| SCHEMBL7497810 | 0.77 | GSK3B (0.44) | CDK1GSK3BCCNB2CCNB1CCNB3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6391902-B2 | TREATMENT OF DISORDERS ASSOCIATED WITH SMOOTH MUSCLE CONTRACTION SUCH AS INCONTINENCE AND IRRITABLE BOWEL SYNDROME | AMERICAN HOME PRODUCTS CORPORATION | 2002-05-21 | — | — | US | claimed |
| US-6391902-B2 | TREATMENT OF DISORDERS ASSOCIATED WITH SMOOTH MUSCLE CONTRACTION SUCH AS INCONTINENCE AND IRRITABLE BOWEL SYNDROME | AMERICAN HOME PRODUCTS CORPORATION | 2002-05-21 | — | — | US | disclosed |
| US-20010047026-A1 | Substituted benzofuranoindoles and indenoindoles as novel potassium channel openers | AMERICAN HOME PRODUCTS CORPORATION | 2001-11-29 | — | — | US | disclosed |
| EP-1135393-A2 | SUBSTITUTED BENZOFURANOINDOLES AND INDENOINDOLES AS NOVEL POTASSIUM CHANNEL OPENERS | AMERICAN HOME PRODUCTS CORPORATION (US) | 2001-09-26 | — | — | EP | disclosed |
| US-6288099-B1 | COMPOUNDS SUCH AS 8-BROMO-10H-BENZO(4,5)FURO(3,2-B)INDOLE-1-CARBOXYLIC ACID USED TO TREAT DISORDERS ASSOCIATED WITH SMOOTH MUSCLE CONTRATION SUCH AS URINARY INCONTINENCE AND IRRITABLE BOWL SYNDROME | AMERICAN HOME PRODUCTS CORPORATION | 2001-09-11 | — | — | US | disclosed |
| WO-2000034285-A2 | SUBSTITUTED BENZOFURANOINDOLES AND INDENOINDOLES AS NOVEL POTASSIUM CHANNEL OPENERS | AMERICAN HOME PRODUCTS CORPORATION (US) | 2000-06-15 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20010047026-A1 | Substituted benzofuranoindoles and indenoindoles as novel potassium channel openers | KCNJ2, KCNN3, KCNN2 | CDK1 2146/4885GSK3B 2791/4885CCNB2 3428/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.