Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA1 | P00915 | 3/20 | 0.46 |
| ▸ | CA2 | P00918 | 3/20 | 0.46 |
| ▸ | CA4 | P22748 | 2/20 | 0.45 |
| ▸ | CA6 | P23280 | 2/20 | 0.45 |
| ▸ | CA12 | O43570 | 1/20 | 0.44 |
| ▸ | CA5A | P35218 | 1/20 | 0.44 |
| ▸ | CA7 | P43166 | 1/20 | 0.44 |
| ▸ | CA9 | Q16790 | 1/20 | 0.44 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.44 |
| ▸ | CA5B | Q9Y2D0 | 1/20 | 0.44 |
| ▸ | CCNB2 | O95067 | 3/20 | 0.43 |
| ▸ | CDK1 | P06493 | 3/20 | 0.43 |
| ▸ | CCNB1 | P14635 | 3/20 | 0.43 |
| ▸ | GSK3B | P49841 | 3/20 | 0.43 |
| ▸ | CCNB3 | Q8WWL7 | 3/20 | 0.43 |
| ▸ | BAZ2B | Q9UIF8 | 1/20 | 0.43 |
| ▸ | MPL | P40238 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Water SCHEMBL7500648 | 0.99 | CA1 (0.46) | CA1CA2CA4CA6CA12 | |
| Water SCHEMBL7500646 | 0.99 | CA1 (0.46) | CA1CA2CA4CA6CA12 | |
| SCHEMBL7500769 | 0.81 | GSK3B (0.46) | CA1CA2CA4CA6CCNB2 | |
| SCHEMBL7492409 | 0.81 | GSK3B (0.55) | CA1CA2CA4CA6CCNB2 | |
| SCHEMBL7501195 | 0.81 | HSP90AA1 (0.55) | CA1CA2CA4CA6CCNB2 | |
| SCHEMBL7493045 | 0.81 | CDK1 (0.57) | CA1CA2CA4CA6CCNB2 | |
| SCHEMBL7504955 | 0.76 | MPL (0.42) | CA1CA2CA4CA6CCNB2 | |
| SCHEMBL7493665 | 0.74 | CA1 (0.50) | CA1CA2CA4CA6CCNB2 | |
| SCHEMBL16085046 | 0.74 | CCNB2 (0.72) | CCNB2CDK1CCNB1GSK3BCCNB3 | |
| SCHEMBL14079332 | 0.73 | PARP1 (0.50) | CA1CA2CA4CA6CCNB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6391902-B2 | TREATMENT OF DISORDERS ASSOCIATED WITH SMOOTH MUSCLE CONTRACTION SUCH AS INCONTINENCE AND IRRITABLE BOWEL SYNDROME | AMERICAN HOME PRODUCTS CORPORATION | 2002-05-21 | — | — | US | disclosed |
| US-20010047026-A1 | Substituted benzofuranoindoles and indenoindoles as novel potassium channel openers | AMERICAN HOME PRODUCTS CORPORATION | 2001-11-29 | — | — | US | disclosed |
| US-6288099-B1 | COMPOUNDS SUCH AS 8-BROMO-10H-BENZO(4,5)FURO(3,2-B)INDOLE-1-CARBOXYLIC ACID USED TO TREAT DISORDERS ASSOCIATED WITH SMOOTH MUSCLE CONTRATION SUCH AS URINARY INCONTINENCE AND IRRITABLE BOWL SYNDROME | AMERICAN HOME PRODUCTS CORPORATION | 2001-09-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20010047026-A1 | Substituted benzofuranoindoles and indenoindoles as novel potassium channel openers | KCNJ2, KCNN3, KCNN2 | CA1 4382/4885CA2 793/4885CA4 3837/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.