Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX2 | P34913 | 3/20 | 0.40 |
| ▸ | FDPS | P14324 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | TACR1 | P25103 | 1/20 | 0.38 |
| ▸ | ADAMTS4 | O75173 | 1/20 | 0.37 |
| ▸ | ADAMTS5 | Q9UNA0 | 1/20 | 0.37 |
| ▸ | PPARA | Q07869 | 2/20 | 0.37 |
| ▸ | PPARG | P37231 | 1/20 | 0.36 |
| ▸ | CNR2 | P34972 | 1/20 | 0.36 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.36 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7497814 | 0.81 | CYP1A2 (0.47) | FDPSTSHRL3MBTL1RAB9APPARA | |
| SCHEMBL7493136 | 0.78 | ALDH1A1 (0.50) | EPHX2L3MBTL1ALDH1A1HTTLMNA | |
| SCHEMBL11038591 | 0.71 | PPARA (0.51) | EPHX2TSHRL3MBTL1ALDH1A1PPARA | |
| SCHEMBL20196974 | 0.70 | PPARA (0.47) | EPHX2ALDH1A1PPARAPPARGALOX5 | |
| SCHEMBL11203948 | 0.69 | PPARA (0.48) | EPHX2TSHRL3MBTL1ALDH1A1PPARA | |
| SCHEMBL11205164 | 0.69 | PPARA (0.56) | EPHX2L3MBTL1ALDH1A1PPARAPPARG | |
| SCHEMBL10383314 | 0.69 | PPARA (0.48) | EPHX2TSHRL3MBTL1ALDH1A1PPARA | |
| SCHEMBL7484970 | 0.68 | MEN1 (0.47) | FDPSL3MBTL1ALDH1A1RAB9APPARA | |
| SCHEMBL10419405 | 0.68 | PPARA (0.47) | EPHX2ALDH1A1PPARAPPARGKCNH2 | |
| SCHEMBL11271408 | 0.68 | EPHX2 (0.46) | EPHX2TSHRL3MBTL1ALDH1A1PPARA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6462042-B1 | TUMOR NECROSIS FACTOR ALPHA CONVERTING ENZYME INHIBITORS; INFLAMMATORY DISEASES, AUTOIMMUNE DISEASES, CANCER, CARDIO-VASCULAR DISEASES, RHEUMATOID ARTHRITIS, OSTEOARTHRITIS, OSTEOPOROSIS, NEURODEGENERATION, ALZHEIMER'S DISEASE, STROKE | DARWIN DISCOVERY LIMITED (GB) | 2002-10-08 | — | — | US | disclosed |
| EP-1237867-A1 | HYDROXAMIC ACID DERIVATIVES AS MATRIX METALLOPROTEINASE (MMP) INHIBITORS | Darwin Discovery Limited (GB) | 2002-09-11 | — | — | EP | disclosed |
| WO-2001044188-A1 | HYDROXAMIC ACID DERIVATIVES AS MATRIX METALLOPROTEINASE (MMP) INHIBITORS | DARWIN DISCOVERY LIMITED (GB) | 2001-06-21 | — | — | WO | disclosed |