Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2A | P29274 | 6/20 | 0.36 |
| ▸ | ADORA1 | P30542 | 6/20 | 0.36 |
| ▸ | PDE4A | P27815 | 13/20 | 0.36 |
| ▸ | PDE4B | Q07343 | 13/20 | 0.36 |
| ▸ | PDE4C | Q08493 | 13/20 | 0.36 |
| ▸ | PDE4D | Q08499 | 13/20 | 0.36 |
| ▸ | PDE3B | Q13370 | 6/20 | 0.36 |
| ▸ | PDE3A | Q14432 | 6/20 | 0.36 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.34 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7495518 | 0.90 | PDE4A (0.46) | PDE4APDE4BPDE4CPDE4DPDE3B | |
| SCHEMBL7489366 | 0.89 | PDE4A (0.42) | PDE4APDE4BPDE4CPDE4DPDE3B | |
| SCHEMBL7486631 | 0.88 | PDE4A (0.41) | PDE4APDE4BPDE4CPDE4DPDE3B | |
| SCHEMBL7491775 | 0.86 | ADORA2A (0.44) | ADORA2AADORA1PDE4APDE4BPDE4C | |
| SCHEMBL7493404 | 0.74 | ADORA2A (0.37) | ADORA2AADORA1 | |
| SCHEMBL6214177 | 0.70 | PDE4A (0.48) | ADORA2AADORA1PDE4APDE4BPDE4C | |
| SCHEMBL6216159 | 0.68 | ADORA2A (0.38) | ADORA2AADORA1PDE4APDE4BPDE4C | |
| SCHEMBL6859886 | 0.68 | PDE4A (0.50) | ADORA2AADORA1PDE4APDE4BPDE4C | |
| SCHEMBL7495122 | 0.67 | PDE4A (0.48) | ADORA2AADORA1PDE4APDE4BPDE4C | |
| SCHEMBL577965 | 0.61 | KDM4E (0.47) | ADORA2AADORA1ADORA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0915093-B1 | AMIDE DERIVATIVES | OTSUKA PHARMA CO LTD (JP) | 2002-11-27 | — | — | EP | disclosed |
| US-6166016-A | Amide derivatives | OTSUKA PHARMACEUTICAL FACTORY, INC. (JP) | 2000-12-26 | — | — | US | disclosed |
| EP-0915093-A1 | AMIDE DERIVATIVES | OTSUKA PHARMACEUTICAL FACTORY, INC. (JP) | 1999-05-12 | — | — | EP | disclosed |