Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | USP5 | P45974 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.39 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.39 |
| ▸ | PARP1 | P09874 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7493945 | 0.86 | LMNA (0.41) | KMT2AALDH1A1HSD17B10HPGDSMN1; SMN2 | |
| SCHEMBL3063858 | 0.83 | POLB (0.56) | KMT2AALDH1A1HSD17B10HPGDSMN1; SMN2 | |
| SCHEMBL7485810 | 0.78 | LMNA (0.40) | KMT2AALDH1A1CYP1A2CYP2C19HSD17B10 | |
| SCHEMBL7490196 | 0.76 | POLB (0.71) | KMT2AALDH1A1HSD17B10SMN1; SMN2POLB | |
| SCHEMBL12362362 | 0.76 | ALDH1A1 (0.60) | KMT2AALDH1A1HSD17B10HPGDSMN1; SMN2 | |
| SCHEMBL16412332 | 0.76 | KDM4E (0.44) | KMT2AALDH1A1HSD17B10HPGDPOLB | |
| SCHEMBL9730975 | 0.76 | HTT (0.70) | KMT2AALDH1A1CYP1A2CYP2C19HPGD | |
| SCHEMBL7348143 | 0.75 | ALDH1A1 (0.64) | KMT2AALDH1A1CYP1A2CYP2C19HSD17B10 | |
| SCHEMBL14543844 | 0.70 | CYP1A2 (0.42) | KMT2AALDH1A1CYP1A2CYP2C19SMN1; SMN2 | |
| SCHEMBL21972278 | 0.69 | STING1 (0.47) | KMT2AALDH1A1HPGDSMN1; SMN2POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0509845-A1 | (+) and (-) enantiomers of 5-aliphatic-6-(benzoxazinyl- or benzothiazinyl)-2,3,4,5-tetrahydropyridazin-3-ones | ORTHO PHARMACEUTICAL CORPORATION (US) | 1992-10-21 | — | — | EP | disclosed |