Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE | P22303 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | TDP2 | O95551 | 1/20 | 0.37 |
| ▸ | CASP7 | P55210 | 1/20 | 0.37 |
| ▸ | CASP9 | P55211 | 1/20 | 0.37 |
| ▸ | CASP6 | P55212 | 1/20 | 0.37 |
| ▸ | CASP8 | Q14790 | 1/20 | 0.37 |
| ▸ | SNCA | P37840 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | NPC1 | O15118 | 2/20 | 0.35 |
| ▸ | RAB9A | P51151 | 2/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11447667 | 0.80 | LMNA (0.52) | ACHELMNATDP2CASP7CASP9 | |
| SCHEMBL11449600 | 0.78 | ALDH1A1 (0.46) | ACHELMNATDP2CASP7CASP9 | |
| SCHEMBL3953679 | 0.78 | SNCA (0.55) | ACHELMNATDP2CASP7CASP9 | |
| SCHEMBL7494054 | 0.78 | AHR (0.44) | ACHETDP2CASP7CASP9CASP6 | |
| SCHEMBL32057233 | 0.78 | SNCA (0.55) | ACHELMNATDP2CASP7CASP9 | |
| SCHEMBL7496212 | 0.73 | ALDH1A1 (0.44) | ACHELMNATDP2CASP7CASP9 | |
| SCHEMBL4811332 | 0.71 | ALDH1A1 (0.60) | ACHELMNASNCAALDH1A1KMT2A | |
| SCHEMBL30776836 | 0.71 | ALDH1A1 (0.46) | TDP2CASP7CASP9CASP6CASP8 | |
| SCHEMBL27198984 | 0.71 | ALDH1A1 (0.46) | TDP2CASP7CASP9CASP6CASP8 | |
| SCHEMBL9387094 | 0.68 | TDP1 (0.39) | ACHELMNATDP2CASP7CASP9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0679641-B1 | SULFONAMIDE AND SULFONIC ESTER DERIVATIVES EACH HAVING TRICYCLIC HETERO RING | EISAI CO LTD (JP) | 2002-10-02 | — | — | EP | disclosed |
| EP-0679641-A1 | SULFONAMIDE AND SULFONIC ESTER DERIVATIVES EACH HAVING TRICYCLIC HETERO RING | Eisai Co., Ltd. (JP) | 1995-11-02 | — | — | EP | disclosed |