Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.65 |
| ▸ | PSEN1 | P49768 | 3/20 | 0.59 |
| ▸ | PSEN2 | P49810 | 3/20 | 0.59 |
| ▸ | APH1B | Q8WW43 | 3/20 | 0.59 |
| ▸ | NCSTN | Q92542 | 3/20 | 0.59 |
| ▸ | APH1A | Q96BI3 | 3/20 | 0.59 |
| ▸ | PSENEN | Q9NZ42 | 3/20 | 0.59 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.57 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.57 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.57 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.57 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.57 |
| ▸ | GUCY1B2 | O75343 | 12/20 | 0.51 |
| ▸ | GUCY1A2 | P33402 | 12/20 | 0.51 |
| ▸ | GUCY1A1 | Q02108 | 12/20 | 0.51 |
| ▸ | GUCY1B1 | Q02153 | 12/20 | 0.51 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.50 |
| ▸ | TP53 | P04637 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15630703 | 0.86 | GUCY1B2 (0.66) | SMN1; SMN2GUCY1B2GUCY1A2GUCY1A1GUCY1B1 | |
| SCHEMBL7216941 | 0.84 | CYP3A4 (0.81) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL7500582 | 0.84 | SMN1; SMN2 (0.61) | SMN1; SMN2PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL17018450 | 0.83 | SMN1; SMN2 (0.74) | SMN1; SMN2PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL15630794 | 0.83 | GUCY1B2 (0.65) | SMN1; SMN2PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL14231969 | 0.83 | GUCY1B2 (0.59) | SMN1; SMN2GUCY1B2GUCY1A2GUCY1A1GUCY1B1 | |
| SCHEMBL11067466 | 0.82 | GUCY1B2 (0.65) | SMN1; SMN2PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL15630778 | 0.82 | SMN1; SMN2 (0.60) | SMN1; SMN2GUCY1B2GUCY1A2GUCY1A1GUCY1B1 | |
| SCHEMBL7496145 | 0.82 | ATP4A (0.64) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL14231967 | 0.82 | GUCY1B2 (0.58) | SMN1; SMN2GUCY1B2GUCY1A2GUCY1A1GUCY1B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0971920-B1 | COMPOUNDS FOR INHIBITION OF GASTRIC ACID SECRETION | ASTRAZENECA AB (SE) | 2002-06-05 | — | — | EP | disclosed |
| US-6265415-B1 | ANTIULCER AGENT | ASTRAZENECA AB (SE) | 2001-07-24 | — | — | US | disclosed |
| EP-0971920-A1 | COMPOUNDS FOR INHIBITION OF GASTRIC ACID SECRETION | Astra Aktiebolag (SE) | 2000-01-19 | — | — | EP | disclosed |
| WO-1998037080-A1 | COMPOUNDS FOR INHIBITION OF GASTRIC ACID SECRETION | ASTRA AKTIEBOLAG (SE) | 1998-08-27 | — | — | WO | disclosed |