Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATP4A | P20648 | 2/20 | 0.64 |
| ▸ | ATP4B | P51164 | 2/20 | 0.64 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.61 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.61 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.61 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.61 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.61 |
| ▸ | PSEN1 | P49768 | 4/20 | 0.48 |
| ▸ | PSEN2 | P49810 | 4/20 | 0.48 |
| ▸ | APH1B | Q8WW43 | 4/20 | 0.48 |
| ▸ | NCSTN | Q92542 | 4/20 | 0.48 |
| ▸ | APH1A | Q96BI3 | 4/20 | 0.48 |
| ▸ | PSENEN | Q9NZ42 | 4/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | BLM | P54132 | 1/20 | 0.47 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.47 |
| ▸ | GUCY1B2 | O75343 | 3/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7504054 | 0.91 | CYP3A4 (0.73) | ATP4AATP4BCYP1A2CYP3A4CYP2D6 | |
| SCHEMBL7216941 | 0.86 | CYP3A4 (0.81) | ATP4AATP4BCYP1A2CYP3A4CYP2D6 | |
| SCHEMBL1814241 | 0.84 | ATP4A (0.60) | ATP4AATP4BCYP1A2CYP3A4CYP2D6 | |
| SCHEMBL10561303 | 0.83 | CYP1A2 (0.56) | ATP4AATP4BCYP1A2CYP3A4CYP2D6 | |
| SCHEMBL7495209 | 0.82 | SMN1; SMN2 (0.65) | CYP1A2CYP3A4CYP2D6CYP2C9CYP2C19 | |
| SCHEMBL1814178 | 0.80 | ATP4A (0.55) | ATP4AATP4BCYP1A2CYP3A4CYP2D6 | |
| SCHEMBL7499510 | 0.80 | ATP4A (0.66) | ATP4AATP4BCYP1A2CYP3A4CYP2D6 | |
| SCHEMBL1818160 | 0.79 | ATP4A (0.53) | ATP4AATP4BCYP1A2CYP3A4CYP2D6 | |
| SCHEMBL2189537 | 0.79 | ATP4A (0.71) | ATP4AATP4BCYP1A2CYP3A4CYP2D6 | |
| SCHEMBL7502903 | 0.78 | ATP4A (0.52) | ATP4AATP4BCYP1A2CYP3A4CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0971920-B1 | COMPOUNDS FOR INHIBITION OF GASTRIC ACID SECRETION | ASTRAZENECA AB (SE) | 2002-06-05 | — | — | EP | disclosed |
| US-6265415-B1 | ANTIULCER AGENT | ASTRAZENECA AB (SE) | 2001-07-24 | — | — | US | disclosed |
| EP-0971920-A1 | COMPOUNDS FOR INHIBITION OF GASTRIC ACID SECRETION | Astra Aktiebolag (SE) | 2000-01-19 | — | — | EP | disclosed |
| WO-1998037080-A1 | COMPOUNDS FOR INHIBITION OF GASTRIC ACID SECRETION | ASTRA AKTIEBOLAG (SE) | 1998-08-27 | — | — | WO | disclosed |