Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | ESR1 | P03372 | 1/20 | 0.44 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | JAK2 | O60674 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.41 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.41 |
| ▸ | HTR1A | P08908 | 1/20 | 0.41 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.41 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.41 |
| ▸ | DRD1 | P21728 | 1/20 | 0.41 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.41 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12833638 | 0.86 | TP53 (0.44) | ESR1KCNH2NPC1JAK2RAB9A | |
| SCHEMBL157807 | 0.79 | MEN1 (0.51) | TDP1ESR1KCNH2MEN1KMT2A | |
| SCHEMBL107013 | 0.79 | CNR2 (0.49) | TDP1ESR1MEN1KMT2ANPSR1 | |
| SCHEMBL2589900 | 0.79 | MEN1 (0.51) | TDP1ESR1KCNH2MEN1KMT2A | |
| SCHEMBL18074044 | 0.77 | CNR2 (0.48) | TDP1ESR1MEN1KMT2ANPSR1 | |
| Bromide SCHEMBL10687133 | 0.77 | MEN1 (0.50) | TDP1ESR1KCNH2MEN1KMT2A | |
| Hydrochloric Acid SCHEMBL2141325 | 0.77 | CNR2 (0.48) | TDP1ESR1MEN1KMT2ANPSR1 | |
| SCHEMBL18460748 | 0.77 | ALDH1A1 (0.38) | TDP1ESR1KCNH2MEN1KMT2A | |
| SCHEMBL20543278 | 0.77 | MEN1 (0.52) | TDP1ESR1KCNH2MEN1KMT2A | |
| SCHEMBL96161 | 0.77 | MAPT (0.55) | TDP1ESR1MEN1KMT2ANPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2292610-A1 | Macrolides with VEGF transcription suppression activity | MERCIAN CORPORATION (JP) | 2011-03-09 | — | — | EP | disclosed |
| EP-2277880-A1 | Macrolides with VEGF transcription suppression activity | Eisai R&D Management Co., Ltd. (JP) | 2011-01-26 | — | — | EP | disclosed |
| US-4499100-A | CARDIOUVASCULAR DISORDERS | SYNTEX (U.S.A.) INC. (US) | 1985-02-12 | — | — | US | disclosed |