Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRA1 | P14867 | 9/20 | 0.60 |
| ▸ | GABRG2 | P18507 | 9/20 | 0.60 |
| ▸ | GABRB3 | P28472 | 9/20 | 0.60 |
| ▸ | GABRA5 | P31644 | 9/20 | 0.60 |
| ▸ | GABRA3 | P34903 | 9/20 | 0.60 |
| ▸ | GABRA2 | P47869 | 9/20 | 0.60 |
| ▸ | GABRP | O00591 | 8/20 | 0.60 |
| ▸ | GABRD | O14764 | 8/20 | 0.60 |
| ▸ | GABRB1 | P18505 | 8/20 | 0.60 |
| ▸ | GABRB2 | P47870 | 8/20 | 0.60 |
| ▸ | GABRA4 | P48169 | 8/20 | 0.60 |
| ▸ | GABRE | P78334 | 8/20 | 0.60 |
| ▸ | GABRA6 | Q16445 | 8/20 | 0.60 |
| ▸ | GABRG1 | Q8N1C3 | 8/20 | 0.60 |
| ▸ | GABRG3 | Q99928 | 8/20 | 0.60 |
| ▸ | GABRQ | Q9UN88 | 8/20 | 0.60 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.55 |
| ▸ | MAPT | P10636 | 4/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30480076 | 0.77 | GABRP (0.75) | GABRA1GABRG2GABRB3GABRA5GABRA3 | |
| SCHEMBL1180609 | 0.77 | GABRP (0.75) | GABRA1GABRG2GABRB3GABRA5GABRA3 | |
| SCHEMBL966651 | 0.77 | GABRP (0.75) | GABRA1GABRG2GABRB3GABRA5GABRA3 | |
| SCHEMBL9288910 | 0.77 | CYP17A1 (0.44) | GABRA1GABRG2GABRB3GABRA5GABRA3 | |
| SCHEMBL29381558 | 0.76 | GABRA1 (1.00) | GABRA1GABRG2GABRB3GABRA5GABRA3 | |
| SCHEMBL30302588 | 0.76 | GABRA1 (1.00) | GABRA1GABRG2GABRB3GABRA5GABRA3 | |
| SCHEMBL1180278 | 0.76 | GABRA1 (1.00) | GABRA1GABRG2GABRB3GABRA5GABRA3 | |
| SCHEMBL10857122 | 0.74 | GABRA1 (0.75) | GABRA1GABRG2GABRB3GABRA5GABRA3 | |
| Hydrochloric Acid SCHEMBL28704925 | 0.74 | GABRA1 (0.97) | GABRA1GABRG2GABRB3GABRA5GABRA3 | |
| SCHEMBL8141088 | 0.74 | GABRA1 (0.75) | GABRA1GABRG2GABRB3GABRA5GABRA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0823909-B1 | NOVEL HETEROCYCLIC CHEMISTRY | BRITISH TECH GROUP INT (GB) | 2002-09-11 | — | — | EP | disclosed |
| US-5834482-A | 3-(1,2,4-OXA- OR THIAZOLYL),9-((PHENYL,4-HYDROXYPIPERIDIN-1-YL)ALKYL-BETA-CARBOLINES AS INHIBITORS FOR THE UPTAKE OF GAMMA-AMINOBUTYRIC ACID VIA THE GAT-4 SUBTYPE CARRIER; ANTI-EPILEPTIC AND ANXIOLYTIC AGENTS; DYSKINESIAS; MUSCLE DISORDER | NOVO NORDISK A/S (DK) | 1998-11-10 | — | — | US | disclosed |
| EP-0823909-A1 | NOVEL HETEROCYCLIC CHEMISTRY | NOVO NORDISK A/S (DK) | 1998-02-18 | — | — | EP | disclosed |
| WO-1996034865-A1 | NOVEL HETEROCYCLIC CHEMISTRY | NOVO NORDISK A/S (DK) | 1996-11-07 | — | — | WO | disclosed |