Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FAAH | O00519 | 3/20 | 0.55 |
| ▸ | HTR1A | P08908 | 1/20 | 0.49 |
| ▸ | HTR7 | P34969 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | DRD4 | P21917 | 1/20 | 0.47 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.45 |
| ▸ | CYSLTR2 | Q9NS75 | 1/20 | 0.43 |
| ▸ | CYSLTR1 | Q9Y271 | 1/20 | 0.43 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.43 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.42 |
| ▸ | PKM | P14618 | 1/20 | 0.42 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17289123 | 0.89 | FAAH (0.65) | FAAHHTR1AHTR7MEN1MAPT | |
| SCHEMBL1331198 | 0.89 | FAAH (0.65) | FAAHHTR1AHTR7MEN1MAPT | |
| SCHEMBL23750987 | 0.85 | FAAH (0.55) | FAAHHTR1AHTR7MEN1MAPT | |
| SCHEMBL13041008 | 0.84 | FAAH (0.58) | FAAHHTR1AHTR7MEN1MAPT | |
| SCHEMBL1331611 | 0.84 | FAAH (0.58) | FAAHHTR1AHTR7MEN1MAPT | |
| SCHEMBL6584608 | 0.84 | FAAH (0.60) | FAAHHTR1AHTR7MEN1MAPT | |
| SCHEMBL6588623 | 0.82 | FAAH (0.53) | FAAHHTR1AHTR7MEN1MAPT | |
| SCHEMBL1331766 | 0.81 | HRH3 (0.63) | FAAHHTR1AHTR7MEN1MAPT | |
| SCHEMBL1332790 | 0.80 | SLC2A1 (0.51) | FAAHHTR1AHTR7MEN1MAPT | |
| SCHEMBL13150413 | 0.80 | SIGMAR1 (0.59) | FAAHKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0905133-B1 | Tetrazole derivatives as LTD4 and H1 antagonists | KOWA CO (JP) | 2002-04-24 | — | — | EP | disclosed |
| US-6121286-A | ANTILEUKOTRIENE ACTIVITY AND ANTIHISTAMINIC ACTIVITY, FOR TREATING ASTHMA; COMPOUNDS SUCH AS 6-METHOXY-3-(2-(3-(2-QUINOLYLMETHOXY)BENZYL)TETRAZOLYL)QUINOLIN-2-ONE | KOWA CO., LTD. (JP) | 2000-09-19 | — | — | US | disclosed |
| US-6117886-A | EXCELLENT ANTILEUKOTRIENE ACTIVITY AND ANTIHISTAMINIC ACTIVITY, AND IS USEFUL FOR THE PREVENTION AND TREATMENT OF, FOR EXAMPLE, ASTHMA. | KOWA CO., LTD. (JP) | 2000-09-12 | — | — | US | disclosed |
| EP-0905133-A1 | Tetrazole derivatives as LTD4 and H1 antagonists | KOWA CO. LTD. (JP) | 1999-03-31 | — | — | EP | disclosed |