Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRL1 | P41146 | 15/20 | 0.48 |
| ▸ | OPRM1 | P35372 | 10/20 | 0.48 |
| ▸ | SLC6A2 | P23975 | 4/20 | 0.45 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.45 |
| ▸ | CACNA1G | O43497 | 1/20 | 0.45 |
| ▸ | CACNA1H | O95180 | 1/20 | 0.45 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.43 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.43 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.43 |
| ▸ | CYP2B6 | P20813 | 1/20 | 0.43 |
| ▸ | PRCP | P42785 | 1/20 | 0.43 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.43 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.43 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.43 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.43 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.43 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.43 |
| ▸ | GRIN3A | Q8TCU5 | 1/20 | 0.43 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7492753 | 0.88 | OPRL1 (0.48) | OPRL1OPRM1OPRK1CACNA1GCACNA1H | |
| SCHEMBL7492029 | 0.88 | OPRL1 (0.44) | OPRL1OPRM1SLC6A2OPRK1CACNA1G | |
| SCHEMBL7489304 | 0.87 | CACNA1G (0.51) | OPRL1OPRM1SLC6A2OPRK1CACNA1G | |
| SCHEMBL7489124 | 0.86 | CACNA1G (0.47) | OPRL1OPRM1SLC6A2OPRK1CACNA1G | |
| SCHEMBL7493212 | 0.86 | CYP2D6 (0.49) | OPRL1OPRM1SLC6A2OPRK1CACNA1G | |
| SCHEMBL7487456 | 0.85 | CACNA1G (0.42) | OPRL1OPRM1SLC6A2OPRK1CACNA1G | |
| SCHEMBL6834480 | 0.85 | CACNA1G (0.52) | OPRL1OPRM1SLC6A2OPRK1CACNA1G | |
| Hydrochloric Acid SCHEMBL7490044 | 0.85 | OPRM1 (0.47) | OPRL1OPRM1SLC6A2OPRK1CACNA1G | |
| Hydrochloric Acid SCHEMBL7488802 | 0.85 | OPRL1 (0.47) | OPRL1OPRM1CACNA1GCACNA1H | |
| Hydrochloric Acid SCHEMBL7487124 | 0.85 | OPRL1 (0.43) | OPRL1OPRM1SLC6A2OPRK1CACNA1G |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6423725-B1 | ANALGESICS | PFIZER INC | 2002-07-23 | — | — | US | disclosed |
| EP-1049689-B1 | 4-(2-KETO-1-BENZIMIDAZOLINYL)PIPERIDINE COMPOUNDS AS ORL1-RECEPTOR AGONISTS | PFIZER (US) | 2002-06-26 | — | — | EP | disclosed |