SCHEMBL7495997

SCHEMBL7495997

COc1ccc(-c2cc3c(N4CCc5ccccc54)ncnc3[nH]2)cc1

nearest known ligand 0.57

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KDM4E B2RXH2 2/20 0.57
MAPT P10636 2/20 0.57
HPGD P15428 2/20 0.57
HSD17B10 Q99714 2/20 0.57
SMN1; SMN2 Q16637 1/20 0.57
NPSR1 Q6W5P4 1/20 0.57
EGFR P00533 5/20 0.56
CSF1R P07333 2/20 0.55
KIT P10721 5/20 0.52
PRMT5 O14744 6/20 0.52
HRH4 Q9H3N8 1/20 0.51
NPC1 O15118 1/20 0.51
ALDH1A1 P00352 1/20 0.51
TP53 P04637 1/20 0.51
MAPK1 P28482 1/20 0.51
RAB9A P51151 1/20 0.51
TDP1 Q9NUW8 1/20 0.51
TUBB4A P04350 1/20 0.48
TUBB P07437 1/20 0.48
PDGFRB P09619 1/20 0.48

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7496197 0.88 CSF1R (0.50) KDM4EMAPTHPGDHSD17B10SMN1; SMN2
SCHEMBL7495638 0.82 CSF1R (0.48) KDM4EMAPTHPGDHSD17B10SMN1; SMN2
SCHEMBL7499406 0.82 SMN1; SMN2 (0.56) KDM4EMAPTHPGDHSD17B10SMN1; SMN2
SCHEMBL7495627 0.76 SMN1; SMN2 (0.49) KDM4EMAPTHPGDHSD17B10SMN1; SMN2
SCHEMBL7494890 0.74 KIT (0.46) CSF1RKITHRH4
SCHEMBL31053042 0.74 TUBB4A (0.64) KDM4EMAPTHPGDHSD17B10SMN1; SMN2
SCHEMBL6185124 0.72 EGFR (1.00) KDM4EMAPTHPGDHSD17B10SMN1; SMN2
SCHEMBL8646018 0.72 TUBB4A (0.76) KDM4EMAPTHPGDHSD17B10SMN1; SMN2
SCHEMBL14076606 0.72 EGFR (0.58) EGFRCSF1RKITPRMT5HRH4
Hydrochloric Acid SCHEMBL6179838 0.71 EGFR (1.00) KDM4EMAPTHPGDHSD17B10SMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0888349-B1 PYRROLOPYRIMIDINES AND PROCESSES FOR THEIR PREPARATION NOVARTIS AG (CH) 2002-05-22 EP claimed
US-6140317-A AS INHIBITORS OF PROTEIN KINASES AND HAVE ANTITUMOUR ACTIVITY NOVARTIS AG (CH) 2000-10-31 US claimed
EP-0888349-A1 PYRROLOPYRIMIDINES AND PROCESSES FOR THEIR PREPARATION Novartis AG (CH) 1999-01-07 EP claimed
WO-1997027199-A1 PYRROLOPYRIMIDINES AND PROCESSES FOR THEIR PREPARATION NOVARTIS AG (CH) 1997-07-31 WO claimed
EP-0888349-B1 PYRROLOPYRIMIDINES AND PROCESSES FOR THEIR PREPARATION NOVARTIS AG (CH) 2002-05-22 EP disclosed
US-6140317-A AS INHIBITORS OF PROTEIN KINASES AND HAVE ANTITUMOUR ACTIVITY NOVARTIS AG (CH) 2000-10-31 US disclosed