Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLK4 | O00444 | 1/20 | 0.45 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.45 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.45 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.45 |
| ▸ | AKT3 | Q9Y243 | 1/20 | 0.45 |
| ▸ | CDK4 | P11802 | 1/20 | 0.43 |
| ▸ | CCND1 | P24385 | 1/20 | 0.43 |
| ▸ | ACHE | P22303 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 3/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | LMNA | P02545 | 3/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | HPGD | P15428 | 2/20 | 0.36 |
| ▸ | PDE4A | P27815 | 1/20 | 0.36 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.36 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.36 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21765723 | 0.77 | CDK4 (0.60) | PLK4MAPK9LIMK1CLK4AKT3 | |
| SCHEMBL30174980 | 0.77 | CDK4 (0.60) | PLK4MAPK9LIMK1CLK4AKT3 | |
| SCHEMBL28435895 | 0.77 | CDK4 (0.47) | PLK4MAPK9LIMK1CLK4AKT3 | |
| SCHEMBL6217225 | 0.76 | FEN1 (0.41) | MEN1KMT2AALDH1A1LMNAMAPT | |
| SCHEMBL250205 | 0.76 | ERN1 (0.36) | MEN1KMT2AALDH1A1LMNAMAPT | |
| SCHEMBL933390 | 0.76 | HTR2A (0.51) | MEN1KMT2AALDH1A1LMNAMAPT | |
| SCHEMBL7493525 | 0.76 | ALDH1A1 (0.48) | MEN1KMT2AALDH1A1LMNAMAPT | |
| SCHEMBL7490077 | 0.76 | CYP2A6 (0.47) | CDK4CCND1MEN1KMT2AALDH1A1 | |
| SCHEMBL11292985 | 0.74 | MEN1 (0.40) | ACHEMEN1KMT2ALMNAMAPT | |
| SCHEMBL29655578 | 0.73 | SLC2A1 (0.49) | MEN1KMT2AALDH1A1MAPTPTGS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1226141-A1 | HETEROCYCLIC SUBSTITUTED PYRAZOLONES | CEPHALON, INC. (US) | 2002-07-31 | — | — | EP | disclosed |
| WO-2001032653-A1 | HETEROCYCLIC SUBSTITUTED PYRAZOLONES | CEPHALON, INC. (US) | 2001-05-10 | — | — | WO | disclosed |