SCHEMBL250205

SCHEMBL250205

Cc1[nH]c2cccc(I)c2c1C=O

nearest known ligand 0.40

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ERN1 O75460 1/20 0.36
GPR17 Q13304 1/20 0.36
HPGD P15428 1/20 0.36
GFER P55789 1/20 0.36
PDPK1 O15530 1/20 0.35
HTR2A P28223 1/20 0.35
HTR2C P28335 1/20 0.35
PTGS1 P23219 1/20 0.35
PTGS2 P35354 1/20 0.35
CDK1 P06493 1/20 0.35
CDK2 P24941 1/20 0.35
MEN1 O00255 4/20 0.34
MAPT P10636 4/20 0.34
KMT2A Q03164 4/20 0.34
ALDH1A1 P00352 2/20 0.34
LMNA P02545 1/20 0.34
CYP2A6 P11509 2/20 0.33
AHR P35869 2/20 0.33
PIM1 P11309 1/20 0.33
PIM3 Q86V86 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6217225 0.79 FEN1 (0.41) ERN1HPGDGFERHTR2AHTR2C
SCHEMBL7493525 0.79 ALDH1A1 (0.48) ERN1GPR17HPGDGFERMEN1
SCHEMBL29952632 0.79 MEN1 (0.39) ERN1GPR17PDPK1CDK1CDK2
SCHEMBL933390 0.79 HTR2A (0.51) ERN1HPGDGFERHTR2AHTR2C
SCHEMBL7490077 0.79 CYP2A6 (0.47) ERN1GPR17HPGDGFERHTR2A
SCHEMBL11292985 0.78 MEN1 (0.40) ERN1HPGDGFERHTR2AHTR2C
SCHEMBL29655578 0.77 SLC2A1 (0.49) ERN1HPGDHTR2CPTGS1PTGS2
SCHEMBL7496063 0.76 PLK4 (0.45) HPGDGFERPTGS2MEN1MAPT
SCHEMBL10936852 0.74 HPGD (0.39) ERN1HPGDGFERHTR2AHTR2C
SCHEMBL248974 0.71 HPGD (0.61) HPGDGFERMEN1MAPTKMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2012001308-A9 METHOD FOR SYNTHESIZING ERGOLINE ALKALOIDS FROM INDOLIC BICYCLIC COMPOUNDS BY DOUBLE CYCLIZATION, RESULTING MATERIALS, AND INTERMEDIATE MATERIALS CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (FR) 2012-03-22 WO disclosed
WO-2012001308-A1 METHOD FOR SYNTHESIZING ERGOLINE ALKALOIDS FROM INDOLIC BICYCLIC COMPOUNDS BY DOUBLE CYCLIZATION, RESULTING MATERIALS, AND INTERMEDIATE MATERIALS CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (FR) 2012-01-05 WO disclosed