Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Lithium Ion. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 10/20 | 0.82 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.82 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.82 |
| ▸ | MEN1 | O00255 | 4/20 | 0.82 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.82 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.82 |
| ▸ | LIMK1 | P53667 | 3/20 | 0.66 |
| ▸ | IKBKB | O14920 | 2/20 | 0.60 |
| ▸ | HPGD | P15428 | 4/20 | 0.58 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.58 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.58 |
| ▸ | HTR1A | P08908 | 1/20 | 0.57 |
| ▸ | HTR2A | P28223 | 1/20 | 0.57 |
| ▸ | HTR7 | P34969 | 1/20 | 0.57 |
| ▸ | HTR6 | P50406 | 1/20 | 0.57 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.57 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.57 |
| ▸ | GAA | P10253 | 1/20 | 0.55 |
| ▸ | MTOR | P42345 | 1/20 | 0.53 |
| ▸ | NPC1 | O15118 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6217262 | 0.97 | MAPT (0.86) | MAPTALDH1A1KDM4EMEN1KMT2A | |
| SCHEMBL7496360 | 0.96 | MAPT (0.84) | MAPTALDH1A1KDM4EMEN1KMT2A | |
| SCHEMBL16583614 | 0.90 | MAPT (1.00) | MAPTALDH1A1KDM4EMEN1KMT2A | |
| SCHEMBL4194506 | 0.88 | LIMK1 (0.82) | MAPTALDH1A1KDM4EMEN1KMT2A | |
| SCHEMBL19769223 | 0.86 | MAPT (0.93) | MAPTALDH1A1KDM4EMEN1KMT2A | |
| SCHEMBL6217354 | 0.86 | MAPT (0.69) | MAPTALDH1A1KDM4EMEN1KMT2A | |
| SCHEMBL4860812 | 0.84 | IKBKB (0.83) | MAPTALDH1A1KDM4EMEN1KMT2A | |
| SCHEMBL15583810 | 0.84 | HPGD (0.71) | MAPTALDH1A1KDM4EMEN1KMT2A | |
| SCHEMBL30701209 | 0.84 | HPGD (0.71) | MAPTALDH1A1KDM4EMEN1KMT2A | |
| SCHEMBL27474356 | 0.84 | MAPT (0.67) | MAPTALDH1A1KDM4EMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1171443-A1 | BICYCLIC HETEROAROMATIC COMPOUNDS USEFUL AS LH AGONISTS | Akzo Nobel N.V. (NL) | 2002-01-16 | — | — | EP | disclosed |
| WO-2000061586-A1 | BICYCLIC HETEROAROMATIC COMPOUNDS USEFUL AS LH AGONISTS | AKZO NOBEL N.V. (NL) | 2000-10-19 | — | — | WO | disclosed |