Sugi Predict

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SCHEMBL6217262

SCHEMBL6217262

Nc1c(C(=O)O)sc2nc(-c3ccccc3)cc(-c3ccccc3)c12

nearest known ligand 0.86

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ MAPT P10636 10/20 0.86
▸ ALDH1A1 P00352 7/20 0.86
▸ KDM4E B2RXH2 6/20 0.86
▸ MEN1 O00255 4/20 0.86
▸ KMT2A Q03164 4/20 0.86
▸ TDP1 Q9NUW8 2/20 0.86
▸ LIMK1 P53667 3/20 0.69
▸ IKBKB O14920 2/20 0.63
▸ HPGD P15428 4/20 0.61
▸ NPSR1 Q6W5P4 1/20 0.61
▸ TLR9 Q9NR96 1/20 0.61
▸ HTR1A P08908 1/20 0.60
▸ HTR2A P28223 1/20 0.60
▸ HTR7 P34969 1/20 0.60
▸ HTR6 P50406 1/20 0.60
▸ L3MBTL1 Q9Y468 3/20 0.59
▸ MAPK1 P28482 2/20 0.59
▸ GAA P10253 1/20 0.57
▸ MTOR P42345 1/20 0.55
▸ NPC1 O15118 1/20 0.51

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7496360 0.99 MAPT (0.84) MAPTALDH1A1KDM4EMEN1KMT2A
Lithium Ion SCHEMBL7496352 0.97 MAPT (0.82) MAPTALDH1A1KDM4EMEN1KMT2A
SCHEMBL16583614 0.93 MAPT (1.00) MAPTALDH1A1KDM4EMEN1KMT2A
SCHEMBL4194506 0.90 LIMK1 (0.82) MAPTALDH1A1KDM4EMEN1KMT2A
SCHEMBL6217354 0.88 MAPT (0.69) MAPTALDH1A1KDM4EMEN1KMT2A
SCHEMBL19769223 0.88 MAPT (0.93) MAPTALDH1A1KDM4EMEN1KMT2A
SCHEMBL4860812 0.86 IKBKB (0.83) MAPTALDH1A1KDM4EMEN1KMT2A
SCHEMBL15583810 0.86 HPGD (0.71) MAPTALDH1A1KDM4EMEN1KMT2A
SCHEMBL30701209 0.86 HPGD (0.71) MAPTALDH1A1KDM4EMEN1KMT2A
SCHEMBL27474356 0.86 MAPT (0.67) MAPTALDH1A1KDM4EMEN1KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1171443-B1 BICYCLIC HETEROAROMATIC COMPOUNDS USEFUL AS LH AGONISTS AKZO NOBEL NV (NL) 2005-07-13 — — EP disclosed
US-6841553-B2 Bicyclic heteroaromatic compounds useful as LH agonists AKZO NOBEL N.V. (NL) 2005-01-11 — — US disclosed
US-20030212081-A1 Bicyclic heteroaromatic compounds useful as LH agonists MERCK SHARP & DOHME B.V. (NL) 2003-11-13 — — US disclosed
US-6569863-B1 Luteinizing hormone (LH) agonists for controlling fertility AKZO NOBEL NV (NL) 2003-05-27 — — US disclosed
EP-1171443-A1 BICYCLIC HETEROAROMATIC COMPOUNDS USEFUL AS LH AGONISTS Akzo Nobel N.V. (NL) 2002-01-16 — — EP disclosed
WO-2000061586-A1 BICYCLIC HETEROAROMATIC COMPOUNDS USEFUL AS LH AGONISTS AKZO NOBEL N.V. (NL) 2000-10-19 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20030212081-A1 Bicyclic heteroaromatic compounds useful as LH agonists LHCGR, GNRHR, FSHR MAPT 4619/4885ALDH1A1 757/4885KDM4E 2123/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.