Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.49 |
| ▸ | PROKR1 | Q8TCW9 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.49 |
| ▸ | GFER | P55789 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 4/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | SMYD3 | Q9H7B4 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.41 |
| ▸ | HSP90AB1 | P08238 | 2/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | STAT3 | P40763 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4059188 | 0.84 | POLB (0.59) | PROKR1LMNAGFERKDM4EHPGD | |
| SCHEMBL7498578 | 0.83 | LMNA (0.49) | SMN1; SMN2LMNAHSD17B10KDM4EHPGD | |
| SCHEMBL6179731 | 0.82 | MEN1 (0.61) | SMN1; SMN2PROKR1LMNAHSD17B10GFER | |
| SCHEMBL6179175 | 0.82 | PROKR1 (0.53) | SMN1; SMN2PROKR1LMNAHSD17B10GFER | |
| SCHEMBL939096 | 0.82 | PROKR1 (0.63) | PROKR1GFERKDM4EHPGDALDH1A1 | |
| SCHEMBL937205 | 0.82 | PROKR1 (0.63) | SMN1; SMN2PROKR1LMNAHSD17B10GFER | |
| SCHEMBL30667713 | 0.80 | PROKR1 (0.61) | PROKR1GFERHPGDALDH1A1MEN1 | |
| SCHEMBL1859158 | 0.80 | PROKR1 (0.61) | PROKR1GFERHPGDALDH1A1MEN1 | |
| SCHEMBL1862840 | 0.80 | CHRNA7 (0.57) | PROKR1GFER | |
| SCHEMBL28388805 | 0.80 | RAB9A (0.64) | SMN1; SMN2HPGDALDH1A1RAB9AKCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1218376-A4 | TYROSINE KINASE INHIBITORS | MERCK & CO INC (US) | 2002-11-20 | — | — | EP | disclosed |
| EP-1218376-A1 | TYROSINE KINASE INHIBITORS | Merck & Co., Inc. (US) | 2002-07-03 | — | — | EP | disclosed |
| WO-2001017995-A1 | TYROSINE KINASE INHIBITORS | MERCK & CO., INC. (US) | 2001-03-15 | — | — | WO | disclosed |