Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 5/20 | 0.41 |
| ▸ | DRD3 | P35462 | 4/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | DRD2 | P14416 | 3/20 | 0.38 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | KDM2B | Q8NHM5 | 4/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7493087 | 0.91 | KDM2B (0.45) | HTR6ALDH1A1KDM4EKDM2BSMN1; SMN2 | |
| SCHEMBL7495270 | 0.86 | HTR6 (0.56) | HTR6KDM4EDRD2CYP3A4CYP2C19 | |
| SCHEMBL7501687 | 0.82 | HTR6 (0.45) | HTR6DRD3DRD2HRH3CYP3A4 | |
| SCHEMBL7499961 | 0.78 | HTR6 (0.56) | HTR6KDM4EDRD2CYP3A4CYP2C19 | |
| SCHEMBL2064417 | 0.77 | HTR6 (0.46) | HTR6ALDH1A1KDM4EGAADRD2 | |
| SCHEMBL2065542 | 0.71 | HTR6 (0.45) | HTR6ALDH1A1KDM4EKDM2BSMN1; SMN2 | |
| SCHEMBL7499257 | 0.70 | HTR6 (0.42) | HTR6KDM4ECYP2C19CYP2C9 | |
| SCHEMBL10557200 | 0.69 | ALDH1A1 (0.41) | HTR6ALDH1A1CYP2C9 | |
| SCHEMBL21147084 | 0.69 | ALDH1A1 (0.41) | HTR6ALDH1A1CYP3A4CYP2C19CYP1A2 | |
| SCHEMBL2063988 | 0.68 | HTR6 (0.58) | HTR6DRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1204662-A1 | AZAINDOLES HAVING SEROTONIN RECEPTOR AFFINITY | NPS Allelix Corp. (CA) | 2002-05-15 | — | — | EP | claimed |
| WO-2001012629-A1 | AZAINDOLES HAVING SEROTONIN RECEPTOR AFFINITY | NPS ALLELIX CORP. (US) | 2001-02-22 | — | — | WO | claimed |
| EP-1204662-A1 | AZAINDOLES HAVING SEROTONIN RECEPTOR AFFINITY | NPS Allelix Corp. (CA) | 2002-05-15 | — | — | EP | disclosed |
| WO-2001012629-A1 | AZAINDOLES HAVING SEROTONIN RECEPTOR AFFINITY | NPS ALLELIX CORP. (US) | 2001-02-22 | — | — | WO | disclosed |