Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSPO | P30536 | 1/20 | 0.60 |
| ▸ | PLK4 | O00444 | 1/20 | 0.44 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.44 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.44 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.44 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.44 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.42 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.42 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.42 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7493872 | 0.89 | TSPO (0.63) | TSPOPLK4MAPK8MAPK9AURKB | |
| SCHEMBL7750398 | 0.87 | TSPO (0.69) | TSPOPLK4MAPK8MAPK9AURKB | |
| SCHEMBL7497324 | 0.86 | TSPO (0.57) | TSPOPLK4MAPK8MAPK9AURKB | |
| SCHEMBL7493004 | 0.81 | TSPO (0.61) | TSPO | |
| SCHEMBL7498096 | 0.81 | TSPO (0.56) | TSPOPLK4MAPK8MAPK9AURKB | |
| SCHEMBL5702522 | 0.80 | TSPO (0.74) | TSPO | |
| SCHEMBL7499582 | 0.79 | TSPO (0.51) | TSPO | |
| SCHEMBL5702540 | 0.78 | TSPO (0.81) | TSPO | |
| SCHEMBL7750489 | 0.78 | TP53 (0.53) | TSPO | |
| SCHEMBL5702800 | 0.78 | TSPO (0.68) | TSPO |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1000063-B1 | 4-OXO-3,5-DIHYDRO-4H-PYRIDAZINO[4,5-b]INDOLE-1-ACETAMIDE DERIVATIVES, THEIR PREPARATION AND THEIR APPLICATION IN THERAPY | SANOFI SYNTHELABO (FR) | 2002-10-23 | — | — | EP | disclosed |
| US-6262045-B1 | TREATMENT OF ANXIETY; SLEEP DISORDER; EPILEPSY; SPASTICITY; MUSCLE CONTRACTURE OR AN EXTRAPYRAMIDAL SYNDROM; INDUCING OR MAINTAINING ANAESTHESIA | SANOFI-SYNTHELABO (FR) | 2001-07-17 | — | — | US | disclosed |