SCHEMBL749709

SCHEMBL749709

Nc1ncc(-c2ncccn2)s1

nearest known ligand 0.46

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CSNK2A1 P68400 1/20 0.46
MAPK14 Q16539 1/20 0.44
BACE1 P56817 1/20 0.44
NOS1 P29475 3/20 0.43
LIMK1 P53667 1/20 0.42
HDAC1 Q13547 1/20 0.39
ALDH1A1 P00352 4/20 0.39
NPC1 O15118 3/20 0.39
MAPT P10636 3/20 0.39
RAB9A P51151 3/20 0.39
SMN1; SMN2 Q16637 2/20 0.39
KDM4E B2RXH2 2/20 0.38
TP53 P04637 1/20 0.38
PI4KA P42356 2/20 0.37
PI4KB Q9UBF8 2/20 0.37
PIK3CD O00329 1/20 0.37
PIP5K1C O60331 1/20 0.37
PIK3CG P48736 1/20 0.37
PIK3CA P42336 2/20 0.37
HPGD P15428 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL21242477 0.80 NOS1 (0.55) CSNK2A1MAPK14BACE1NOS1LIMK1
SCHEMBL17889606 0.75 MAPK14 (0.61) CSNK2A1MAPK14NOS1LIMK1HDAC1
SCHEMBL11996720 0.73 ADORA2A (0.40) MAPK14HDAC1NPC1MAPTRAB9A
SCHEMBL25377978 0.72 BACE1 (0.41) CSNK2A1MAPK14BACE1NOS1LIMK1
SCHEMBL30482478 0.72 BACE1 (0.41) CSNK2A1MAPK14BACE1NOS1LIMK1
SCHEMBL69900 0.71 CSNK2A1 (0.62) CSNK2A1MAPK14BACE1LIMK1ALDH1A1
SCHEMBL15641472 0.71 CYP2A6 (0.59) CSNK2A1LIMK1HDAC1ALDH1A1SMN1; SMN2
SCHEMBL30279938 0.71 CYP2A6 (0.59) CSNK2A1LIMK1HDAC1ALDH1A1SMN1; SMN2
Hydrochloric Acid SCHEMBL31452773 0.70 CYP2A6 (0.58) CSNK2A1LIMK1HDAC1ALDH1A1SMN1; SMN2
Bromide SCHEMBL22834317 0.70 CSNK2A1 (0.61) CSNK2A1MAPK14BACE1LIMK1ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 43 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3025724-B1 CYCLIN DEPENDENT KINASE INHIBITORS AND METHODS OF USE UNIV NORTH CAROLINA CHAPEL HILL (US) 2018-07-11 EP claimed
US-9808461-B2 Protection of renal tissues from ischemia through inhibition of the proliferative kinases CDK4 and CDK6 THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL (US) 2017-11-07 US claimed
EP-3025724-A1 CYCLIN DEPENDENT KINASE INHIBITORS AND METHODS OF USE The University of North Carolina At Chapel Hill (US) 2016-06-01 EP claimed
EP-2429566-B1 CYCLIN DEPENDENT KINASE INHIBITORS AND METHODS OF USE UNIV NORTH CAROLINA (US) 2016-01-06 EP claimed
US-20150111896-A1 HEMATOPOIETIC PROTECTION AGAINST CHEMOTHERAPEUTIC COMPOUNDS USING SELECTIVE CYCLIN-DEPENDENT KINASE 4/6 INHIBITORS NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT 2015-04-23 US claimed
US-20130303543-A1 PROTECTION OF RENAL TISSUES FROM ISCHEMIA THROUGH INHIBITION OF THE PROLIFERATIVE KINASES CDK4 AND CDK6 THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL (US) 2013-11-14 US claimed
US-20110224227-A1 HEMATOPOIETIC PROTECTION AGAINST CHEMOTHERAPEUTIC COMPOUNDS USING SELECTIVE CYCLIN-DEPENDENT KINASE 4/6 INHIBITORS NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT 2011-09-15 US claimed
US-20110224221-A1 HEMATOPOIETIC PROTECTION AGAINST IONIZING RADIATION USING SELECTIVE CYCLIN-DEPENDENT KINASE 4/6 INHIBITORS NORTH CAROLINA AT CHAPEL HILL, THE UNIVERSITY OF 2011-09-15 US claimed
EP-2341911-A2 HEMATOPOIETIC PROTECTION AGAINST CHEMOTHERAPEUTIC COMPOUNDS USING SELECTIVE CYCLIN-DEPENDENT KINASE 4/6 INHIBITORS The University of North Carolina At Chapel Hill (US) 2011-07-13 EP claimed
EP-2341906-A2 HEMATOPOIETIC PROTECTION AGAINST IONIZING RADIATION USING SELECTIVE CYCLIN-DEPENDENT KINASE 4/6 INHIBITORS The University of North Carolina At Chapel Hill (US) 2011-07-13 EP claimed
WO-2010039997-A9 HEMATOPOIETIC PROTECTION AGAINST CHEMOTHERAPEUTIC COMPOUNDS USING SELECTIVE CYCLIN-DEPENDENT KINASE 4/6 INHIBITORS THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL (US) 2011-05-05 WO claimed
WO-2010051127-A2 HEMATOPOIETIC PROTECTION AGAINST IONIZING RADIATION USING SELECTIVE CYCLIN-DEPENDENT KINASE 4/6 INHIBITORS THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL (US) 2010-05-06 WO claimed
WO-2010039997-A2 HEMATOPOIETIC PROTECTION AGAINST CHEMOTHERAPEUTIC COMPOUNDS USING SELECTIVE CYCLIN-DEPENDENT KINASE 4/6 INHIBITORS THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL (US) 2010-04-08 WO claimed
EP-4709853-A1 METHODS OF PREVENTING ON-TARGET GENOTOXICITY INDUCED BY NUCLEASES Institut National de la Santé et de la Recherche Médicale (FR) 2026-03-18 EP disclosed
WO-2024235844-A1 METHODS OF PREVENTING ON-TARGET GENOTOXICITY INDUCED BY NUCLEASES Institut National de la Santé et de la Recherche Médicale (FR) 2024-11-21 WO disclosed
US-20220280519-A1 COMBINATIONS OF AGENTS TO TREAT HEMATOLOGICAL MALIGNANCIES OREGON HEALTH & SCIENCE UNIVERSITY (US) 2022-09-08 US disclosed
WO-2010039997-A9 HEMATOPOIETIC PROTECTION AGAINST CHEMOTHERAPEUTIC COMPOUNDS USING SELECTIVE CYCLIN-DEPENDENT KINASE 4/6 INHIBITORS THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL (US) 2011-05-05 WO disclosed
WO-2010132725-A2 CYCLIN DEPENDENT KINASE INHIBITORS AND METHODS OF USE THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL (US) 2010-11-18 WO disclosed
WO-2010051127-A2 HEMATOPOIETIC PROTECTION AGAINST IONIZING RADIATION USING SELECTIVE CYCLIN-DEPENDENT KINASE 4/6 INHIBITORS THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL (US) 2010-05-06 WO disclosed
WO-2010039997-A2 HEMATOPOIETIC PROTECTION AGAINST CHEMOTHERAPEUTIC COMPOUNDS USING SELECTIVE CYCLIN-DEPENDENT KINASE 4/6 INHIBITORS THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL (US) 2010-04-08 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20110224227-A1 HEMATOPOIETIC PROTECTION AGAINST CHEMOTHERAPEUTIC COMPOUNDS USING SELECTIVE CYCLIN-DEPENDENT KINASE 4/6 INHIBITORS CDK6, CDK4, CDKN1A CSNK2A1 664/4885MAPK14 370/4885BACE1 4795/4885
US-20130303543-A1 PROTECTION OF RENAL TISSUES FROM ISCHEMIA THROUGH INHIBITION OF THE PROLIFERATIVE KINASES CDK4 AND CDK6 CDK4, CDK6, CDK3 CSNK2A1 435/4885MAPK14 995/4885BACE1 3955/4885
US-20110224221-A1 HEMATOPOIETIC PROTECTION AGAINST IONIZING RADIATION USING SELECTIVE CYCLIN-DEPENDENT KINASE 4/6 INHIBITORS CDK4, CDK6, CDKN1A CSNK2A1 1010/4885MAPK14 414/4885BACE1 4574/4885
US-20150111896-A1 HEMATOPOIETIC PROTECTION AGAINST CHEMOTHERAPEUTIC COMPOUNDS USING SELECTIVE CYCLIN-DEPENDENT KINASE 4/6 INHIBITORS CDK6, CDK4, CDKN1A CSNK2A1 664/4885MAPK14 370/4885BACE1 4795/4885
US-20220280519-A1 COMBINATIONS OF AGENTS TO TREAT HEMATOLOGICAL MALIGNANCIES MCL1, MPL, BCL9 CSNK2A1 1336/4885MAPK14 2298/4885BACE1 4883/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.