Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GART | P22102 | 6/20 | 0.43 |
| ▸ | DHFR | P00374 | 3/20 | 0.39 |
| ▸ | ATIC | P31939 | 3/20 | 0.33 |
| ▸ | CA12 | O43570 | 1/20 | 0.32 |
| ▸ | CA1 | P00915 | 1/20 | 0.32 |
| ▸ | CA2 | P00918 | 1/20 | 0.32 |
| ▸ | CA9 | Q16790 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7497455 | 1.00 | GART (0.43) | GARTDHFRATICCA12CA1 | |
| SCHEMBL7553633 | 0.87 | GART (0.58) | GARTDHFRATIC | |
| SCHEMBL7496781 | 0.87 | GART (0.58) | GARTDHFRATIC | |
| SCHEMBL8017846 | 0.86 | GART (0.40) | GARTDHFRCA12CA1CA2 | |
| SCHEMBL8017849 | 0.86 | GART (0.40) | GARTDHFRCA12CA1CA2 | |
| SCHEMBL7496547 | 0.85 | GART (0.43) | GARTDHFRATICALOX5 | |
| SCHEMBL7497802 | 0.85 | GART (0.43) | GARTDHFRATICALDH1A1MAPK1 | |
| SCHEMBL7496744 | 0.79 | GART (0.58) | GARTDHFRATIC | |
| SCHEMBL7494746 | 0.79 | DHFR (0.42) | GARTDHFR | |
| SCHEMBL9383614 | 0.77 | GART (0.56) | GARTDHFRATICALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0904271-A4 | 5,6,7,8-TETRAHYDROPYRIDO[2,3-d]PYRIMIDINES | UNIV PRINCETON (US) | 2002-01-23 | — | — | EP | disclosed |
| US-6066639-A | ANTITUMOR AGENTS | THE TRUSTEES OF PRINCETON UNIVERSITY (US) | 2000-05-23 | — | — | US | disclosed |
| EP-0904271-A1 | 5,6,7,8-TETRAHYDROPYRIDO[2,3-d]PYRIMIDINES | THE TRUSTEES OF PRINCETON UNIVERSITY (US) | 1999-03-31 | — | — | EP | disclosed |
| WO-1997041115-A1 | 5,6,7,8-TETRAHYDROPYRIDO[2,3-d]PYRIMIDINES | THE TRUSTEES OF PRINCETON UNIVERSITY (US) | 1997-11-06 | — | — | WO | disclosed |