Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CSF1R | P07333 | 1/20 | 0.59 |
| ▸ | GSK3B | P49841 | 2/20 | 0.56 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.56 |
| ▸ | CDK1 | P06493 | 1/20 | 0.56 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.56 |
| ▸ | GSK3A | P49840 | 1/20 | 0.56 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.56 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.56 |
| ▸ | CCNB3 | Q8WWL7 | 1/20 | 0.56 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.53 |
| ▸ | EIF2AK2 | P19525 | 1/20 | 0.52 |
| ▸ | KIT | P10721 | 2/20 | 0.49 |
| ▸ | IKBKB | O14920 | 1/20 | 0.48 |
| ▸ | CHUK | O15111 | 1/20 | 0.48 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.46 |
| ▸ | EGFR | P00533 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4903666 | 0.85 | EGFR (0.57) | CSF1RGSK3BCCNB2CDK1CCNB1 | |
| SCHEMBL7495582 | 0.84 | CSF1R (0.59) | CSF1RGSK3BCCNB2CDK1CCNB1 | |
| SCHEMBL1897594 | 0.80 | EGFR (0.55) | CSF1RKITEGFR | |
| SCHEMBL30588943 | 0.80 | EGFR (0.55) | CSF1RKITEGFR | |
| SCHEMBL8089650 | 0.78 | CCNT1 (0.47) | CSF1RCHUKEGFR | |
| SCHEMBL27444977 | 0.77 | EGFR (0.55) | CSF1RKITEGFR | |
| SCHEMBL7497561 | 0.77 | RIPK1 (0.49) | CSF1RGSK3BEIF2AK2KITEGFR | |
| SCHEMBL2444894 | 0.76 | CCNB2 (0.64) | CSF1RGSK3BCCNB2CDK1CCNB1 | |
| SCHEMBL2461351 | 0.76 | EGFR (0.57) | CSF1RCDK1MAP4K4EGFR | |
| SCHEMBL7504170 | 0.75 | CSF1R (0.54) | CSF1REGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0836605-B1 | PYRROLOPYRIMIDINES AND PROCESSES FOR THE PREPARATION THEREOF | NOVARTIS AG (CH) | 2002-02-06 | — | — | EP | disclosed |
| US-6140332-A | Pyrrolopyrimidines and processes for the preparation thereof | NOVARTIS AG (CH) | 2000-10-31 | — | — | US | disclosed |
| US-6096749-A | ANTITUMOR, EPIDERMAL GROWTH FACTOR | NOVARTIS CORPORATION (US) | 2000-08-01 | — | — | US | disclosed |
| EP-0836605-A1 | PYRROLOPYRIMIDINES AND PROCESSES FOR THE PREPARATION THEREOF | Novartis AG (CH) | 1998-04-22 | — | — | EP | disclosed |
| WO-1997002266-A1 | PYRROLOPYRIMIDINES AND PROCESSES FOR THE PREPARATION THEREOF | NOVARTIS AG (CH) | 1997-01-23 | — | — | WO | disclosed |
| EP-0682027-A1 | Pyrrolopyrimidine derivatives with antiproliferative action | CIBA-GEIGY AG (CH) | 1995-11-15 | — | — | EP | disclosed |