Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 14/20 | 0.53 |
| ▸ | HTR2C | P28335 | 13/20 | 0.53 |
| ▸ | HTR2B | P41595 | 11/20 | 0.53 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.48 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.48 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.48 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | GFER | P55789 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.35 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.35 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4826360 | 1.00 | HTR2A (0.53) | HTR2AHTR2CHTR2BCYP1A2CYP3A4 | |
| SCHEMBL4822351 | 1.00 | HTR2A (0.53) | HTR2AHTR2CHTR2BCYP1A2CYP3A4 | |
| SCHEMBL17988784 | 0.80 | MEN1 (0.38) | CYP2D6LMNATSHRSLC6A4 | |
| SCHEMBL2460600 | 0.80 | ALDH1A1 (0.37) | CYP2D6LMNATSHRL3MBTL1 | |
| SCHEMBL12969624 | 0.79 | HTR2A (0.49) | HTR2AHTR2CHTR2BCYP1A2CYP3A4 | |
| Ammonia Solution, Strong SCHEMBL4822367 | 0.77 | ALDH1A1 (0.41) | HTR2AHTR2CLMNASLC6A4 | |
| SCHEMBL7495949 | 0.75 | HTR2A (0.40) | HTR2AHTR2BCYP2D6 | |
| SCHEMBL4829069 | 0.74 | ALDH1A1 (0.33) | CYP2D6TSHRSLC6A2SLC6A4SLC6A3 | |
| SCHEMBL14184489 | 0.74 | HTR2A (0.67) | HTR2AHTR2CHTR2BCYP1A2CYP3A4 | |
| SCHEMBL6198125 | 0.74 | HTR2C (0.67) | HTR2AHTR2CHTR2BCYP1A2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1167681-C | Condensed indoline derivatives and their use as 5HT, in particular 5HT2C receptor ligands | О | 2004-09-22 | — | — | CN | claimed |
| CN-1379761-A | Fused indoline derivatives and their use as 5HT, in particular 5HT2C, receptor ligands | VERNALIS RESAERCH LTD (GB) | 2002-11-13 | — | — | CN | claimed |
| CN-1167681-C | Condensed indoline derivatives and their use as 5HT, in particular 5HT2C receptor ligands | О | 2004-09-22 | — | — | CN | disclosed |
| CN-1379761-A | Fused indoline derivatives and their use as 5HT, in particular 5HT2C, receptor ligands | VERNALIS RESAERCH LTD (GB) | 2002-11-13 | — | — | CN | disclosed |
| EP-1202964-A1 | CONDENSED INDOLINE DERIVATIVES AND THEIR USE AS 5HT, IN PARTICULAR 5HT2C, RECEPTOR LIGANDS | VERNALIS RESEARCH LIMITED (GB) | 2002-05-08 | — | — | EP | disclosed |
| WO-2001012602-A1 | CONDENSED INDOLINE DERIVATIVES AND THEIR USE AS 5HT, IN PARTICULAR 5HT2C, RECEPTOR LIGANDS | VERNALIS RESEARCH LIMITED (GB) | 2001-02-22 | — | — | WO | disclosed |