Sugi Predict

Sugi Predict / Compounds / SCHEMBL2460600

SCHEMBL2460600

SCHEMBL2460600

ClCN1CCc2ccc3ccccc3c21

nearest known ligand 0.37

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ ALDH1A1 P00352 4/20 0.37
▸ MEN1 O00255 1/20 0.37
▸ USP2 O75604 1/20 0.37
▸ CDK4 P11802 1/20 0.37
▸ ALOX15 P16050 1/20 0.37
▸ CCND1 P24385 1/20 0.37
▸ KMT2A Q03164 1/20 0.37
▸ CYP2A6 P11509 2/20 0.35
▸ TDP1 Q9NUW8 2/20 0.35
▸ TSHR P16473 1/20 0.35
▸ HSD17B10 Q99714 1/20 0.35
▸ KDM4E B2RXH2 2/20 0.33
▸ GAA P10253 1/20 0.33
▸ MAPT P10636 1/20 0.33
▸ HPRT1 P00492 1/20 0.33
▸ HCRTR1 O43613 1/20 0.33
▸ NPC1 O15118 2/20 0.33
▸ LMNA P02545 2/20 0.33
▸ TP53 P04637 2/20 0.33
▸ RAB9A P51151 2/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL17988784 0.83 MEN1 (0.38) ALDH1A1MEN1USP2CDK4ALOX15
SCHEMBL7498570 0.80 HTR2A (0.53) TSHRLMNACYP2D6L3MBTL1
SCHEMBL4826360 0.80 HTR2A (0.53) TSHRLMNACYP2D6L3MBTL1
SCHEMBL4822351 0.80 HTR2A (0.53) TSHRLMNACYP2D6L3MBTL1
Ammonia Solution, Strong SCHEMBL4822367 0.80 ALDH1A1 (0.41) ALDH1A1MEN1USP2CDK4ALOX15
SCHEMBL7495949 0.78 HTR2A (0.40) ALDH1A1MEN1USP2CDK4ALOX15
SCHEMBL4829069 0.77 ALDH1A1 (0.33) ALDH1A1MEN1USP2CDK4ALOX15
SCHEMBL1408982 0.75 KDM4E (0.45) ALDH1A1MEN1KMT2ACYP2A6TDP1
SCHEMBL1408791 0.74 ALDH1A1 (0.39) ALDH1A1CYP2A6TDP1TSHRHSD17B10
SCHEMBL5743895 0.71 HTR2C (0.40) SIGMAR1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20170298118-A1 METHODS FOR SCREENING ANTIBODIES SEATTLE GENETICS, INC. (US) 2017-10-19 — — US disclosed
US-9725500-B2 Methods for screening antibodies SEATTLE GENETICS, INC. (US) 2017-08-08 — — US disclosed
EP-2542576-B1 METHODS FOR SCREENING ANTIBODIES SEATTLE GENETICS INC (US) 2016-04-20 — — EP disclosed
US-9278124-B2 Hypoxia and hyaluronan and markers thereof for diagnosis and monitoring of diseases and conditions and related methods HALOZYME, INC. (US) 2016-03-08 — — US disclosed
WO-2014062856-A1 HYPOXIA AND HYALURONAN AND MARKERS THEREOF FOR DIAGNOSIS AND MONITORING OF DISEASES AND CONDITIONS AND RELATED METHODS HALOZYME, INC. (US) 2014-04-24 — — WO disclosed
EP-2542576-A1 METHODS FOR SCREENING ANTIBODIES Seattle Genetics, Inc. (US) 2013-01-09 — — EP disclosed
US-20120322686-A1 METHODS FOR SCREENING ANTIBODIES SEATTLE GENETICS, INC. (US) 2012-12-20 — — US disclosed
WO-2011109308-A1 METHODS FOR SCREENING ANTIBODIES SEATTLE GENETICS, INC. (US) 2011-09-09 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20170298118-A1 METHODS FOR SCREENING ANTIBODIES FCGR2A, FCGR3B, FCGR1A ALDH1A1 1196/4885MEN1 2613/4885USP2 973/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.