⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9478728 | 0.96 | LMNA (0.44) | — | |
| SCHEMBL6507209 | 0.96 | — | — | |
| SCHEMBL1289416 | 0.96 | — | — | |
| SCHEMBL9481388 | 0.96 | LMNA (0.44) | — | |
| SCHEMBL9478813 | 0.96 | LMNA (0.44) | — | |
| SCHEMBL460354 | 0.96 | — | — | |
| SCHEMBL359512 | 0.87 | — | — | |
| 1,4-Butanediol SCHEMBL18642519 | 0.76 | SMN1; SMN2 (0.58) | — | |
| 1,4-Butanediol SCHEMBL30932429 | 0.76 | — | — | |
| 1,4-Butanediol SCHEMBL18642509 | 0.76 | SMN1; SMN2 (0.58) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 183 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117126180-A | Biphenyl compound as immunomodulator as well as preparation method and application thereof | 深圳微芯生物科技股份有限公司 | 2023-11-28 | — | — | CN | claimed |
| EP-2303283-A2 | ANTI-CANCER COMBINATION THERAPY | Katholieke Universiteit Leuven K.U. Leuven R&D (BE) | 2011-04-06 | — | — | EP | claimed |
| US-20110065663-A1 | ANTI-CANCER COMBINATION THERAPY | KATHOLIEKE UNIVERSITEIT LEUVEN, K.U. LEUVEN R&D | 2011-03-17 | — | — | US | claimed |
| WO-2009138507-A2 | ANTI-CANCER COMBINATION THERAPY | KATHOLIEKE UNIVERSITEIT LEUVEN, K.U. LEUVEN R&D (BE) | 2009-11-19 | — | — | WO | claimed |
| CN-101426792-A | Pyrazolopyrimidines as therapeutic agents | ABBOTT GMBH & CO KG (DE) | 2009-05-06 | — | — | CN | claimed |
| EP-1330452-B1 | PYRAZINE DERIVATIVES AS MODULATORS OF TYROSINE KINASES | ORTHO MCNEIL PHARM INC (US) | 2008-11-26 | — | — | EP | claimed |
| CN-1520298-A | Pyrazolopyrimidines as therapeutic agents | �����ʩ���عɷݹ�˾ | 2004-08-11 | — | — | CN | claimed |
| US-6710048-B2 | SELECTIVE INHIBITORS OF VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR TYROSINE KINASE; TO TREAT SOLID-TUMOR CANCERS, ANGIOGENESIS, DIABETIC RETINOPATHY, RHEUMATOID ARTHRITIS, ENDOMETRIOSIS AND PSORIASIS | ORTHO-MCNEIL PHARMACEUTICAL, INC. | 2004-03-23 | — | — | US | claimed |
| EP-1330452-A2 | PYRAZINE DERIVATIVES AS MODULATORS OF TYROSINE KINASES | Ortho-McNeil Pharmaceutical, Inc. (US) | 2003-07-30 | — | — | EP | claimed |
| US-20030060629-A1 | Pyrazine derivatives as modulators of tyrosine kinases | ORTHO-MCNEIL PHARMACEUTICAL, INC. | 2003-03-27 | — | — | US | claimed |
| US-6514977-B1 | For treating p38 kinase mediated disorders | G.D. SEARLE & COMPANY | 2003-02-04 | — | — | US | claimed |
| WO-2002024681-A2 | PYRAZINE DERIVATIVES AS MODULATORS OF TYROSINE KINASES | ORTHO-MCNEIL PHARMACEUTICAL, INC. (US) | 2002-03-28 | — | — | WO | claimed |
| CN-1342157-A | Substituted pyrazoles ASP38 kinase inhibitors | SEARLE & CO (US) | 2002-03-27 | — | — | CN | claimed |
| EP-0881268-A1 | Fiber-reactive triphendioxazine dyes, process for their preparation and the use thereof | DyStar Textilfarben GmbH & Co. Deutschland KG (DE) | 1998-12-02 | — | — | EP | claimed |
| US-5328902-A | Antibiotics | AMERICAN CYANAMID CO. (US) | 1994-07-12 | — | — | US | claimed |
| EP-0200024-B1 | 3-CYANO-PYRIDINES, PROCESS FOR THEIR PREPARATION AND THEIR PHARMACEUTICAL USE | ARZNEIMITTELWERK DRESDEN GmbH (DE) | 1992-07-01 | — | — | EP | claimed |
| EP-0200024-A2 | 3-Cyano-pyridines, process for their preparation and their pharmaceutical use | ARZNEIMITTELWERK DRESDEN GmbH (DE) | 1986-11-05 | — | — | EP | claimed |
| EP-0006227-B1 | ANTITHROMBOTIC PHARMACEUTICAL PREPARATION CONTAINING 2,2'-DITHIOBIS BENZAMIDE DERIVATIVES AND NEW 2,2'-DITHIOBIS BENZAMIDE DERIVATIVES | KYOWA HAKKO KOGYO CO., LTD (JP) | 1984-12-27 | — | — | EP | claimed |
| CN-117126180-A | Biphenyl compound as immunomodulator as well as preparation method and application thereof | 深圳微芯生物科技股份有限公司 | 2023-11-28 | — | — | CN | disclosed |
| US-3998827-A | HYPOTENSIVE AGENTS | THE UPJOHN COMPANY (US) | 1976-12-21 | — | — | US | disclosed |