Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 4/20 | 0.48 |
| ▸ | NPC1 | O15118 | 2/20 | 0.48 |
| ▸ | PRSS1 | P07477 | 3/20 | 0.46 |
| ▸ | PRSS2 | P07478 | 3/20 | 0.46 |
| ▸ | PRSS3 | P35030 | 3/20 | 0.46 |
| ▸ | TPSAB1 | Q15661 | 3/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | ZAP70 | P43403 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 4/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.39 |
| ▸ | CSGALNACT1 | Q8TDX6 | 1/20 | 0.39 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.39 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.39 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8165421 | 0.83 | KMT2A (0.43) | RAB9ANPC1PRSS1PRSS2PRSS3 | |
| SCHEMBL8491074 | 0.80 | PRSS1 (0.43) | RAB9ANPC1PRSS1PRSS2PRSS3 | |
| SCHEMBL7505093 | 0.80 | PRSS1 (0.41) | RAB9ANPC1PRSS1PRSS2PRSS3 | |
| SCHEMBL892526 | 0.79 | KMT2A (0.47) | RAB9ANPC1PRSS1PRSS2PRSS3 | |
| SCHEMBL8491451 | 0.77 | ELANE (0.64) | — | |
| SCHEMBL8495148 | 0.77 | PRSS1 (0.40) | RAB9ANPC1PRSS1PRSS2PRSS3 | |
| SCHEMBL7208823 | 0.77 | PRSS1 (0.40) | RAB9ANPC1PRSS1PRSS2PRSS3 | |
| SCHEMBL893046 | 0.75 | KMT2A (0.56) | RAB9ANPC1PRSS1PRSS2PRSS3 | |
| SCHEMBL8436306 | 0.70 | PRSS1 (0.51) | RAB9ANPC1PRSS1PRSS2PRSS3 | |
| SCHEMBL1114503 | 0.70 | MEN1 (0.59) | KMT2AHTTSMN1; SMN2MEN1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0954526-A2 | SERINE PROTEASE INHIBITORS | CORTECH, INC. (US) | 1999-11-10 | — | — | EP | disclosed |
| WO-1998024806-A2 | SUBSTITUTED OXADIAZOLE, THIADIAZOLE AND TRIAZOLE SERINE PROTEASE INHIBITORS | CORTECH, INC. (US) | 1998-06-11 | — | — | WO | disclosed |