Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRSS1 | P07477 | 6/20 | 0.40 |
| ▸ | PRSS2 | P07478 | 6/20 | 0.40 |
| ▸ | PRSS3 | P35030 | 6/20 | 0.40 |
| ▸ | TPSAB1 | Q15661 | 6/20 | 0.40 |
| ▸ | RAB9A | P51151 | 3/20 | 0.38 |
| ▸ | NPC1 | O15118 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | ELANE | P08246 | 4/20 | 0.34 |
| ▸ | PSMB5 | P28074 | 1/20 | 0.34 |
| ▸ | CSGALNACT1 | Q8TDX6 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8491074 | 0.79 | PRSS1 (0.43) | PRSS1PRSS2PRSS3TPSAB1RAB9A | |
| SCHEMBL8494793 | 0.77 | ELANE (0.49) | RAB9ANPC1ELANEPOLB | |
| SCHEMBL7499006 | 0.77 | RAB9A (0.48) | PRSS1PRSS2PRSS3TPSAB1RAB9A | |
| SCHEMBL7505093 | 0.73 | PRSS1 (0.41) | PRSS1PRSS2PRSS3TPSAB1RAB9A | |
| SCHEMBL7208823 | 0.73 | PRSS1 (0.40) | PRSS1PRSS2PRSS3TPSAB1RAB9A | |
| SCHEMBL8165421 | 0.72 | KMT2A (0.43) | PRSS1PRSS2PRSS3TPSAB1RAB9A | |
| SCHEMBL27537539 | 0.69 | PRSS1 (0.41) | PRSS1PRSS2PRSS3TPSAB1RAB9A | |
| SCHEMBL8491451 | 0.68 | ELANE (0.64) | ELANE | |
| SCHEMBL892526 | 0.67 | KMT2A (0.47) | PRSS1PRSS2PRSS3TPSAB1RAB9A | |
| SCHEMBL7199926 | 0.66 | ELANE (0.71) | ELANE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5891852-A | Serine protease inhibitors-cycloheptane derivatives | CORTECH, INC. (US) | 1999-04-06 | — | — | US | disclosed |
| US-5869455-A | SUBSTITUTED OXADIAZOLE, THIADIAZOLE AND TRIAZOLE PEPTOIDS WHICH ARE USEFUL AS INHIBITORS OF HUMAN NEUTROPHIL ELASTASE | CORTECH, INC. (US) | 1999-02-09 | — | — | US | disclosed |
| US-5861380-A | OXADIAZOLE, THIADIAZOLE AND TRIAZOLE PEPTOIDS AS INHIBITORS OF HUMAN NEUTROPHIL ELASTASE; ADULT RESPIRATORY DISTRESS SYNDROME; ANTIARTHRITIC,-INFLAMMATORY,-ISCHEMIC,-TUMOR AND -CARCINOGENIC AGENTS AND OTHER HNE-MEDIATED CONDITIONS | CORTECH, INC. (US) | 1999-01-19 | — | — | US | disclosed |
| US-5807829-A | RESPIRATORY SYSTEM DISORDERS; SESPIC SHOCK; ORGAN FAILURE | CORTECH, INC. (US) | 1998-09-15 | — | — | US | disclosed |
| US-5801148-A | Serine protease inhibitors-proline analogs | CORTECH, INC. (US) | 1998-09-01 | — | — | US | disclosed |